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Research Project
Studies of estrogenic chemicals typically involve the examination
of the uterotrophic effect in immature, ovariectomized rodents.
However, very little is known of the mechanism of action of
these chemicals, particularly in non-classical estrogen target
organs such as the liver. My project uses microarray technology
to characterize estrogen- and estrogenic chemical-induced temporal
gene expression profiles of hepatic cultures from mouse, human
and rat. By comparing in vitro to in vivo profiles, a more comprehensive
understanding of the effects of estrogen may be elucidated.
Also, the in vitro model system may potentially be employed
as a diagnostic tool for examining estrogenic properties of
novel chemicals.
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