Contact information
Biochemistry & Molecular Biology
Michigan State University
kimsun5@msu.edu

Education
B.S. Food Science and Technology, 1998
Seoul National University, Korea

M.S. Food Science and Technology, 2000
Seoul National University, Korea

Research Project

My current research project involves studying the utility of human stem cells as in vitro models for toxicity screening. Normal adult human liver and kidney stem cells are selected as viable in vitro models for early receptor-mediated toxicity screening. These cells possess estrogen (ER), aryl hydrocarbon (AhR), peroxisome proliferators-activated (PPAR), and pregnane X (PXR) receptors. Dose- and time dependent TAM, TCDD, CLO, TCZ and RU486-elicited gene expression changes are investigated using microarray and QRT-PCR techniques. Also comparative analysis is conducted to investigate conserved responses and pathway between in vivo rodent and in vitro human models. Advanced statistical approaches and computational data analyzing techniques are utilized to develop pathways of receptor-mediated molecular networks that can be associated with toxicity.

I am also working as a member of the Zacharewski Lab Bioinformatics Group. I support Dr. Burgoon as a database administrator for the dbZach System which is integrated toxicogenomic information management system and am involved in the development of data analysis, data management, mining, and visualization tools.