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Yue-wern Huang, Ph.D.
Post-Doctoral Fellow
Current contact information
Yue-wern Huang, Ph.D.
Assistant Professor
Department of Biological Sciences
University of Missouri-Rolla
105 Schrenk Hall
1870 Miner Circle
Rolla, MO 65409-1120
Tel: 573-341-6589
Fax: 573-341-4821
E-mail: huangy@umr.edu MSU
E-mail: huangyu@pilot.msu.edu
http://www.umr.edu/~huangy
Education
Postdoctoral Fellow, Department of Biochemistry, Michigan State
University, Sept., 1998 to present.
PhD, University of Wisconsin-Madison. August 1998.
MSc, Graduate Institute of Biology, National Taiwan Normal University.
June 1986-June 1988
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Research Project
It has been hypothesized that some chemicals can mimic the
activities of endogenous estrogen, and therefore may adversely
affect human and wildlife reproductive fitness. This is commonly
referred to as endocrine disruption, which has been defined
as alterations of the structure or function(s) of the endocrine
system caused by exogenous chemical substance or mixtures. Endocrine
disrupters include a variety of structurally diverse substances
such as natural products, pesticides, phytoestrogens, pharmaceuticals,
and industrial chemicals. The objectives of my postdoctoral
research are to elucidate mechanisms of endocrine disruption
in amphibians, as well as to test and screen the estrogenic
potency of alleged environmental estrogen mimics using in vitro
and in vivo models.
Three complementary assays are employed:
- competitive binding of chemicals to a glutathione-S-transferase
(GST) fusion Xenopus estrogen receptor (ER) protein,
- chimeric estrogen receptor/reporter gene expression assay,
and
- in vivo studies using RT-PCR to measure vitellogenin mRNA
as a biomarker for exposure to xenoestrogens.
The competitive binding assay uses a bacterially expressed fusion
protein consisting of GST and the ER ligand binding domain (LBD)
of Xenopus laevis. The GST-xERdef fusion protein is partially
purified to greater than 90% purity and subsequently used in a
semi-high throughput competitive binding assay to examine the
ability of potential endocrine disrupters to compete with 17b-estradiol
(E2) for binding to the recombinant ER protein.
The effect of potential endocrine disrupters on in vitro gene
expression is then assessed using a chimeric receptor/reporter
gene assays. The chimeric receptor consists of the LBD from
Xenopus linked to the DNA binding domain (DBD) of Gal4, a yeast
transcription factor. The chimeric receptor is then transiently
transfected with a Gal4-regulated luciferase reporter gene into
MCF-7 human breast cancer cells. The induction of the reporter
gene is an estimate of estrogenic potency of the chemical interested.
In addition, I am currently investigating the use of two Xenopus
cell lines so that the gene expression data would be more relevant
to amphibian species.
Potential endocrine disrupters are also being investigated in
vivo for their ability to induce the expression of vitellogenin,
a precursor molecule for yolk proteins, that is a biomarker
for exposure to estrogenic chemicals. Xenopus laevis will be
treated with potential endocrine disrupters and vitellogenin
mRNA will be measured using a quantitative, competitive reverse
transcription-polymerase chain reaction (RT-PCR) and possibly
an enzyme-linked immunosorbent assay (ELISA). In addition to
identifying and assessing chemicals for estrogenic activity
in an amphibian model, results from these studies will also
indicate the ability of an inexpensive in vitro assay to predict
responses in vivo.
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