Abstracts from Recent Meetings

47th Annual Meeting of the Society of Toxicology. Seattle, WA. (March 16-20, 2007).

  • OpenREP: A community-based deliberation platform for debating dioxin and dioxin-like chemical toxic equivalency data and assigned factors. Burgoon LD and Zacharewski TR. [Abstract] [SciCast]
  • Identification of positionally conserved dioxin response elements in orthologous human, mouse, and rat genes. Cabunoc AE, Burgoon LD, and Zacharewski TR. [Abstract] [Poster]
  • Conserved and divergent gene expression profiles during ethynylestradiol, tamoxifen, and o,p'-DDT induced uterotrophy in the rat uterus. Kwekel JC, Williams KJ and Zacharewski TR. [Abstract] [Poster]
  • Temporal and dose-dependent AhR-mediated gene expression analysis in human liver adult stem cells. Kim S, Dere E, Burgoon LD, Chang CC, and Zacharewski TR. [Abstract] [Poster]
  • Comparative hepatic gene expression elicited by o,p'-DDT in the rat and mouse. Kiyosawa N, Kwekel J, Burgoon LD, and Zacharewski TR. [Abstract] [Poster]

46th Annual Meeting of the Society of Toxicology. Charlotte, NC. (March 25-29, 2007).

  • Assessing AhR-mediated gene expression effects in a novel human liver adult stem cell line. Kim S, Dere E, Burgoon LD, Chang CC, Zacharewski TR. [Abstract] [Poster]
  • Metabolomic analyses of lipid and aqueous liver extracts in TCDD-treated mice. Kent MN, Reo NV, Jahns GL, DelRaso N, Boverhof DR, Burgoon LD, Jump D, Zacharewski TR. [Abstract] [Poster]
  • Comparative toxicogenomics of Ah receptor mediated hepatotoxicity in C57BL/6 mice. N'jai A, Boverhof DR, Burgoon LD, Dere E, Tan Y, Rowlands JC, Budinsky R, Stebbins K, Zacharewski TR. [Abstract] [Poster]
  • Comparative toxicogenomic analysis of the hepatotoxic effects of TCDD in Sprague-Dawley rats and C57BL/6 mice. Tashiro C, Boverhof DR, Burgoon LD, Sharratt B, Chittim B, Harkema J, Mendrick D, Zacharewski TR. [Abstract] [Poster]
  • Comparative toxicogenomic examination of the hepatotoxic effects of 3,3',4,4',5-pentachlorobiphenyl (PCB-126) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in C57BL/6 mice. Kopec AK, Boverhof DR, Burgoon LD, Tashiro C, Chittim B, Zacharewski TR. [Abstract] [Poster]
  • Comparative microarray analysis of toxic and non-toxic aryl hydrocarbon receptor ligands in murine Hepa1c1c7 hepatoma cells. Kiewitt MS, Dere D, Lundback SS, Burgoon LD, Zacharewski TR. [Abstract] [Poster]
  • Comparative analysis of global gene expression responses elicited by TCDD in human HepG2, mouse Hepa1c1c7 and rat H4IIE cell lines. Dere E, Harney AS, Proper SS, Burgoon LD, Zacharewski TR. [Abstract] [Poster]
  • In vivo genome-wide location analysis of TCDD-mediated promoter binding of the aryl hydrocarbon receptor in C57BL/6 hepatic tissue. Burt JW and Zacharewski TR. [Abstract] [Poster]
  • Comparative analysis of the genome binding locations of the aryl hydrocarbon receptor and the aryl hydrocarbon receptor nuclear translocator in TCDD treated Hepa-1c1c7 cells. Griffin P, Burt JW, Zacharewski TR. [Abstract] [Poster]
  • Cross-species comparison of tamoxifen & estrogen induced uterotrophy in rodents. Kwekel JC, Fong CJ, Burgoon LD, Zacharewski TR. [Abstract] [Poster]
  • Comparative analysis of temporal gene expression, morphometry and uterotrophy in O,P'-DDT and ethynylestradiol treated rats. Forgacs AL, Kwekel JC, Burgoon LD, Zacharewski TR. [Abstract] [Poster]
  • Automated quantitative toxicogenomic dose-response modeling. Burgoon LD, Boverhof DR, Zacharewski TR. [Abstract] [Poster]
  • Development of a NMR-based metabolomic analysis methodology for toxicology. Jahns GL, Reo NV, Kent MN, Boverhof DR, Burgoon LD, DelRaso N, Zacharewski TR. [Abstract] [Poster]
  • Inhibition of estrogen-mediated gene expression responses by dioxin in the uteri of C57BL/6 mice. Boverhof DR, Kwekel JC, Burgoon LD, Williams KJ, Zacharewski TR. [Abstract] [Poster]
  • Tamoxifen and ethynylestradiol co-treatment in C57BL/6 mouse uterus: Gross, morphometric and cDNA microarray gene expression analysis. Fong CJ, Burgoon LD, Williams KJ, Forgacs AL, Zacharewski TR. [Abstract] [Poster]

 

44th Annual Meeting of the Society of Toxicology. New Orleans, LA. (March 6-10, 2005).

  • Protocols for the assurance of microarray data quality and process control. Burgoon LD, Eckel-Passow JE, Gennings C, Boverhof DR, Burt JW, Fong CJ, Zacharewski TR. Abstract Platform Presentation
  • dbZach: A comprehensive toxicogenomic information management and knowledge discovery system. Burgoon LD, Boutros PC, Dere E, Doran S, Pai SS, Aiyar R, Vakharia J, Rotman R, Adams A, Lau B, Zacharewski TR. Abstract Platform Presentation
  • Non-additive dose dependent gene expression patterns exhibited by a mixture of 17-alpha ethynylestradiol and genistein in vivo. Gupta R, Burgoon LD, Harney AS, Boverhof DB, Kwekel J, Gennings C, Zacharewski TR. Abstract Poster
  • Effects of estrogen on immature, ovariectomized mice: a multi-approach, tissue-by-tissue comparison. Burt JW, Burgoon LD, Humes D, Harney AS, and Zacharewski TR. Abstract Poster
  • Temporal gene expression analysis of mouse Hepa-1c1c7 cells treated with 17beta-estradiol by cDNA microarray. Fong CJ, Burgoon LD, Gupta R, Humes DG, Zacharewski TR. Abstract Poster
  • Comparative microarray analysis of basal gene expression in mouse Hepa-1c1c7 wild-type and mutant cell lines. Fong CJ, Burgoon LD, Ramer MD, Zacharewski TR. Abstract Poster
  • Microarray examination of TCDD mediated changes in gene expression in Hepa1c1c7 murine hepatoma cells. Dere E, Boverhof DR, Burgoon LD, and Zacharewski TR. Abstract Poster
  • Temporal and dose-dependent hepatic gene expression patterns in mice provide new insights into TCDD-mediated hepatotoxicity. Boverhof DR, Burgoon LD, Tashiro C, Chittim B, Harkema JR, and Zacharewski TR. Abstract Poster
  • Analysis of gene expression during uterine induction and regression in immature, ovariectomized rats following treatment with ethynyl estradiol. Kwekel JC, Dalgleish HA, Burgoon LD, Harkema JR, Zacharewski TR. Abstract
    Poster

MGED 7. Toronto, Canada. (Sept.8-10, 2004).

  • Assessing toxicogenomic data: Analysis of microarray quality control measures. Burgoon LD, Boverhof DR, Burt J, Fong CJ, Ramer M, Zacharewski TR. Abstract
  • dbZach: A comprehensive toxicogenomic information management and knowledge discovery system. Burgoon LD, Boutros PC, Dere E, Doran S, Pai SS, Aiyar R, Vakharia J, Rotman R, Adams A, Lau B, Zacharewski TR Abstract

42nd Annual Meeting of the Society of Toxicology. Salt Lake City, UT. (March 9-13, 2003).

  • Use of an emperical Bayes screening approach and gene ontology annotations to filter and interpret microarray data from the uteri of estrogen-treated mice. Fertuck KC, Eckel JE, Gennings C, Zacharewski TR.Abstract
  • Temporal expression patterns of hepatic genes of immature, ovariectomized mice treated with ethynyl estradiol. Boverhof DR, Fertuck KC, Aiyar R, Burgoon LD, Zacharewski TR.Abstract
  • Temporal effects of AH receptor ligands on CH12LX murine B-cell lymphoma gene expression: cDNA microarray analysis, real-time PCR verification and bioinformatic assessment. Fielden MR, Boverhof DR, Zacharewski TR.Abstract

SCOPE/IUPAC International Symposium on Endocrine Active Substances. Yokohama, Japan (Nov. 21, 2002)

  • Use of a Bayesian screening approach and gene ontology annotations to filter and interpret microarray data from the uteri of estrogen-treated mice. Fertuck KC, Eckel JE, Gennings C, Zacharewski TR.Abstract

Society for Neuroscience Meeting. Orlando, FL (November 2-7, 2002)

  • Developmental exposure to PCBs affects sexual differentiation of the rat anteroventral periventricular nucleus. Ahmed, E.I., Tang, Y.P., Burgoon, L.D., Zacharewski, T.R., Sisk, C.L. Abstract

Environmental Protection Agency Endocrine Disruptors Workshop. Research Triangle Park, NC. (October 29-31, 2002).

Screening and testing assays symposium.

  • Complementary In Vitro and In Vivo Rodent Assays. Fertuck KC Abstract

The Tenth International Conference on Intelligent Systems for Molecular Biology. Edmonton,
Alberta (Aug 3-7, 2002)

  • Development of a relational toxicogenomics database for the prediction of chemical toxicity. Burgoon, L.D., Boutros, P.C., Dere, E., Zacharewski, T.R. Abstract

5th Annual Affymetrix User Group Meeting. Chicago, IL. (April 30 - May 1, 2002).

  • Temporal expression patterns of individual genes in the uteri of immature, ovariectomized mice treated with ethynyl estradiol. Fertuck KC, Zacharewski TR.Abstract

41st Annual Meeting of the Soceity of Toxicology. Nashville, TN (March 17-21, 2002).

  • Retinoic acid induced disruption of cAMP-induced human SVG astroglial cell differentiation: Morphology and global gene expression effects. Burgoon L.D., Kwan K.Y., Fielden M.R., Trosko J.E., Zacharewski T.R. Abstract
  • Development of a relational toxicogenomics database for the prediction of chemical toxicity. Boutros P.C., Burgoon L.D., Zacharewski T.R. Abstract
  • GP3: GenePix post-processing script for automated analysis of raw toxicogenomic microarray data. Dere E., Fielden M.R., Halgren R.G., Zacharewski T.R. Abstract
  • Temporal expression patterns of genes in the uteri of immature, ovariectomized mice treated with ethynyl estradiol. Fertuck K.C., Eckel J., Gennings C., and Zacharewski T.R. Abstract
  • Effects of gestational and lactational exposure to diethylstilbesterol on testicular gene expression using cDNA microarrays and real-time PCR. Fielden, M.R., Halgren R.G., Fong C.J., Chou K., Zacharewski T.R. Abstract
  • Gestational and lactational exposure to estrogenic chemicals does not affect mammary gland development in female mice. Fong C.J., Fielden M.R., Haslam S.Z., Zacharewski T.R. Abstract
  • Effects of gestational and lactational exposure to genistein on sperm quality and testicular gene expression in mice. Samy S.M., Fielden M.R., Chou K., Zacharewski T.R. Abstract

168th National Meeting of the American Association for the Advancement of Science. Boston, MA. (February 14-19, 2002).

Environmental estrogens and women's health symposium.

  • Identification and assessment of endocrine disrupting chemicals. Fertuck KC. Abstract

8th Annual Mount Desert Island Biological Laboratory (MDIBL)

Environmental Health Sciences Symposium - Intracellular Sensors of Environmental Chemicals. Maren Conference Center, Mount Desert Island Biological Laboratory, Salabury Cove, ME. (July 11-12, 2001).

  • Endocrine Disruptor - Estrogen Receptor Interactions: An Investigation into Ligand Preference Differences Amongst Species. Zacharewski, T.R. Abstract.

8th Annual High-Throughput Screening, Genomic, Drug Discovery, Chemoinformatics Conference

Cambridge Healthtech Institute
Making Drug Development Faster, Cheaper and Smarter. Philadelphia, PA. (June 11-13, 2001).

  • Incorporating toxicogenomics into predictive and mechanistic toxicology: a case study. Zacharewski, T.R. Abstract.

40th Annual Meeting of the Society of Toxicology

San Francisco, CA (March 25-29, 2001).

  • Male reproductive and genomic effects of developmental exposure to diethylstilbestrol in mice. Fielden M.R., Halgren R.G., Fong C.J., Chou K., Saama P., Zacharewski T.R. Abstract
  • The effect of maternal diet, gavage stress, corn oil dosing vehicle and data analysis on the outcome and interpretation of reproductive development of mouse offspring. Zacharewski T.R., Fielden M.R.,
    Haslam S.Z. Abstract
  • Stem cell biology in toxicology. Trosko J.E., Kwan K., Upham B., Halgren R.G., Zacharewski T.R. and Chang C.C.Abstract
  • Preferential interaction of PAH-related compounds with the beta isoform of the estrogen receptor. K.C. Fertuck, H. Sikka, J.B. Matthews and T.R. Zacharewski. Abstract
  • Differential interactions of estrogenic chemicals with estrogen receptors from several different species. Zacharewski T.R., Matthews J.B., Celius T., Fertuck K, Huang Y-W. Abstract
  • Identification of residues within human ERa and rainbow trout ER that contribute to temperature sensitivity and interaction with estrogenic compounds. Matthews J.B. and Zacharewski T.R. Abstract
  • Effects of gestational and postnatal exposure of diethylstilbesterol on female reproduction. Han J., Fielden M.R., Halgren R.G., Zacharewski T.R., Saama P.M., Chou K. Abstract

Society for Neuroscience Meeting

New Orleans, LA (Nov. 5-9, 2000)
  • Distribution of androgen receptor mRNA in the green anole brain. Rosen G., Matthews J., Zacharewski T., and Wade J. Abstract

58th Annual EHS Center Directors' Meeting. Detroit, Michigan (Oct. 16, 2000)

Functional Genomics, Proteomics and High Through-put Technologies: Tools for the 21st Century
  • Developing an infrastructure to support toxicogenomic research for the study of male endocrine disruptors. Fielden M.R., Halgren R.G., Fong C.J., Boutros P., Chou K., Saama P., and Zacharewski T.R. Abstract

Environmental Health Sciences Center for Molecular and Cellular Toxicology Annual Symposium

Institute Chemical Toxicology, Detroit, MI (Oct. 16, 2000)

  • Developing an infrastructure to support toxicogenomic research for the study of male endocrine disruptors. Fielden M.R., Halgren R.G., Fong C.J., Boutros P., Chou K., Saama P., and Zacharewski T.R. Abstract
  • dbmTEST: a database of transcripts expressed in spermatogenesis and testis.Halgren R.G., Fielden M.R., Fong C.J., Boutros P., Zacharewski T.R. Abstract

e.hormone Conference

New Orleans, LA (Oct. 15-18, 2000)
  • Preferential interaction of PAH-related compounds with the beta isoform of the estrogen receptor. K.C. Fertuck, H. Sikka, J.B. Matthews and T.R. Zacharewski. Abstract

Early Toxicity Screening in Drug Discovery

Institute for Scientific Exchange, Baltimore, MD
(Oct. 9-12, 2000)
  • Developing an infrastructure to support toxicogenomic research for the study of male endocrine disruptors. Fielden M.R., Halgren R.G., Fong C.J., Boutros P., Chou K., Saama P.M., and Zacharewski T.R. Abstract

Consortium on Environmental and Drug Safety Workshop

Toronto, Ontario, Canada (Sept. 29-Oct. 1, 2000)

  • Developing an infrastructure to support toxicogenomic research for the study of male endocrine disruptors. Fielden M.R., Halgren R.G., Fong C.J., Boutros P., Chou K., Saama P.M., and Zacharewski T.R. Abstract
  • Preferential interaction of PAH-related compounds with the beta isoform of the estrogen receptor. K.C. Fertuck, H. Sikka, J.B. Matthews and T.R. Zacharewski. Abstract

New Techniques to Increase Drug Candidate Survivability - Strategic Research Institute

Philadelphia, PA. (Sept 11-12, 2000)

  • The application of toxicogenomics in predictive toxicology. Zacharewski, T.R. Abstract

New Dimensions in the regulation of gene expression (FEBS meeting).

Island of Spetses, Greece (Aug. 22-29, 2000)

  • Identification of residues within human ERalpha and rainbow trout ER that are important for interaction with estrogenic compounds. J.B. Matthews and T.R. Zacharewski. Abstract

Mechanisms of Toxicity: Gordon Research Conferences

Plymouth, NH (July 23-28, 2000)

  • Assessment of clone identity and sequence fidelity within the IMAGE cDNA Library. Halgren R.G., Fielden M.R., Fong C.J., and Zacharewski T.R. Abstract

Cancer and Molecular Genetics in the Twenty-first Century

Van Andel Research Institute, Grand Rapids, MI (Sept 5-8, 2000)
  • Assessment of clone identity and sequence fidelity within the IMAGE cDNA Library. Halgren R.G., Fielden M.R., Fong C.J., and Zacharewski T.R. Abstract

ENDO2000: Endocrine Society's 82nd Annual Meeting

Toronto, Ontario, Canada (June 21-24, 2000)

  • Effects of gestational and lactational exposure to aroclor 1242 on sperm quality and in vitro fertilizing ability in the aging mouse. Fielden M.R., Halgren R.G., Chou K., Zacharewski T.R. Abstract
  • Gene expression in the mouse testis: development of a murine testis transcriptome by mining public databases. Halgren R.G., Fielden M.R., Zacharewski T.R. Abstract
  • In vitro binding and gene expression of benzo[A]pyrene and hydroxylated benzo[A]pyrene metabolites mediated through the estrogen receptors alpha and beta, and lack of in vivo effects on mouse uterine weight of lactoferrin mRNA expression. K.C. Fertuck, J.B. Matthews and T.R. Zacharewski. Abstract

2000 Keystone Symposia: Nuclear Receptors 2000

Steamboat Springs, CO (March 25-31, 2000)

  • Identification of residues within human ERa that are important for binding of estrogenic compounds. JB Matthews, V Schnecke, L Kuhn, and TR Zacharewski. Abstract

39th Annual Meeting of the Society of Toxicology

Philadelphia, PA (March 18-23, 2000)

  • Differential estrogen receptor binding of estrogenic substances: A comparison across species. JB Matthews, T Celius, R Halgren and TR Zacharewski. Abstract
  • Comparison of the interactions of Bisphenol A and its metabolite Bisphenol A glucuronide with estrogen receptors a and b . JB Matthews and TR Zacharewski. Abstract
  • Gene expression in the mouse testis: development of a murine testis transcriptome by mining public databases. RG Halgren, MR Fielden, and TR Zacharewski. Abstract
  • Establishment of Xenopus laevis as a model for investigating in vitro and in vivo endocrine disruption in amphibians. Y-W Huang, JB Matthews and TR Zacharewski. Abstract
  • Developmental effects of Aroclor 1242 on male offspring after gestational and lactational exposure. MR Fielden, RG Halgren, K Chou and TR Zacharewski. Abstract
  • Cloning of zona radiata proteins from rainbow trout (Oncorhynchus mykiss): A marker for investigating estrogenic endocrine modulators in fish. T Celius, JB Matthews, SA Villalobos, JP Giesy and TR Zacharewski. Abstract
  • Comparison of in vitro binding and gene expression of benzo[a]pyrene and two hydroxylated benzo[a]pyrene metabolites mediated through the estrogen receptors a and b , and lack of in vivo effects on mouse uterine weight or lactoferrin mRNA expression. KC Fertuck, JB Matthews and TR Zacharewski. Abstract

2000 Keystone Symposia: Molecular Toxicology, Toxicogenomics and Bioinformatics Applied to Drug Discovery

Santa Fe, NM (Jan 11-15, 2000)

  • Toxicology in silico: In search of target genes for the nuclear aryl hydrocarbon receptor complex. MR Fielden and TR Zacharewski. Abstract

Society of Environmental Toxicology and Chemistry 20th Annual Meeting

Philadelphia, PA (Nov. 16, 1999)

  • Survey of the in vitro endocrine disrupting activities of different pulp and paper mill effluents. JH Clemons, G Kruzynski, BE McCarry, LM Allan, Z Wu, B Cox, N Bunce, L Tremblay, K Wells, G Van Der Kraak, H Hodgert-Jury, G Hammond and TR Zacharewski. Abstract

Second Annual Endocrine Disruptors Conference. Seoul National University, Seoul, KOREA

(Nov. 24, 1999)

  • Molecular basis for endocrine disruptor - estrogen receptor interactions: a species comparison. TR Zacharewski. Abstract

Japanese Environment Agency's Endocrine Disruptor Conference. Kobe, JAPAN

(Dec. 9, 1999)

  • Prioritization and screening of estrogenic endocrine disruptors using in vitro and in silico approaches. TR Zacharewski. Abstract

National Institute of Health Sciences

Tokyo, JAPAN (Dec. 13, 1999)

  • Molecular basis for endocrine disruptor - estrogen receptor interactions: a species comparison. TR Zacharewski. Abstract

38th Annual Meeting of the Society of Toxicology

New Orleans, LA (March 1999)

  • Molecular cloning of the reptilian, Anolis carolinensis, estrogen receptor ligand binding domain: comparative amino acid sequence analysis to known estrogen receptors. JB Matthews and TR Zacharewski. Abstract
  • Development of a rainbow trout recombinant chimeric receptor reporter bioassay to screen for the potential estrogenicity of environmental contaminants in fish. JH Clemons, JB Matthews and TR Zacharewski. Abstract
  • Estrogen receptor-mediated activities of benzo[a]pyrene: receptor binding, induction of gene expression and uterotrophic effects. KC Fertuck, JB Matthews, JH Clemons, MR Fielden and TR Zacharewski. Abstract
  • Polychlorinated biphenyls (PCBs) exhibit differential binding to recombinant human a and rainbow trout estrogen receptors. JB Matthews and TR Zacharewski. Abstract
  • Quantitative analysis of gene expression array data from TCDD treated mouse hepatoma cells. PM Saama, MR Fielden and TR Zacharewski.Abstract
  • Toxicology in silico: in search of target genes for the nuclear aryl hydrocarbon receptor complex. MR Fielden and TR Zacharewski. Abstract