Christoph Benning
Professor
- M.S. 1986, Albert-Ludwigs Universitaet, Freiburg, Germany
- Ph.D. 1991, Michigan State University
- Postdoctoral Researcher, 1991-93, Michigan State University
- Group Leader, 1993-97, Institut fuer Genbiologische Forschung Berlin GmbH, Berlin, Germany.
benning@msu.edu
215A Biochemistry Building
Michigan State University
East Lansing, MI 48824-1319
Office: 517-355-1609
Lab: 517-353-1999
Current Projects
Lab Home Page
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Christoph Benning Publications
2008
Benning C. A role for lipid trafficking in chloroplast biogenesis. Prog Lipid Res. 2008 Sep;47(5):381-9. Epub 2008 Apr 7. Link to publication
Benning C, Pichersky E. Harnessing plant biomass for biofuels and biomaterials. Plant J. 2008 May;54(4):533-5. Link to publication
Durrett TP, Benning C, Ohlrogge J. Plant triacylglycerols as feedstocks for the production of biofuels. Plant J. 2008 May;54(4):593-607. Link to publication
Lu Y, Savage LJ, Ajjawi I, Imre KM, Yoder DW, Benning C, Dellapenna D, Ohlrogge JB, Osteryoung KW, Weber AP, Wilkerson CG, Last RL. New connections across pathways and cellular processes: Industrialized mutant screening reveals novel associations between diverse phenotypes in Arabidopsis. Plant Physiol. 2008 Feb 8; [Epub ahead of print] See PubMed
Xu C, Moellering ER, Fan J, Benning C. Mutation of a mitochondrial outer membrane protein affects chloroplast lipid biosynthesis. Plant J. 2008 Feb 18; [Epub ahead of print] See PubMed
Wakao S, Andre C, Benning C. Functional analyses of cytosolic glucose-6-phosphate dehydrogenases and their contribution to seed oil accumulation in Arabidopsis. Plant Physiol. 2008 Jan;146(1):277-88. Link to publication or See PubMed
2007
Andre C, Benning C. Arabidopsis seedlings deficient in a plastidic pyruvate kinase are unable to utilize seed storage compounds for germination and establishment. Plant Physiol. 2007 Dec;145(4):1670-80. Link to publication or See PubMed
Awai K, Watanabe H, Benning C, Nishida I. Digalactosyldiacylglycerol is required for better photosynthetic growth of Synechocystis sp. PCC6803 under phosphate limitation. Plant Cell Physiol. 2007 Oct 11; [Epub ahead of print] Link to publication or See PubMed
Lu B, Xu C, Awai K, Jones AD, Benning C. A small ATPase protein of Arabidopsis, TGD3, involved in chloroplast lipid import. J Biol Chem. 2007 Oct 15; [Epub ahead of print] Link to publication or See PubMed
Andre C, Froehlich JE, Moll MR, Benning C. A Heteromeric Plastidic Pyruvate Kinase Complex Involved in Seed Oil Biosynthesis in Arabidopsis. Plant Cell. 2007 Jun;19(6):2006-22. Epub 2007 Jun 8. See PubMed
2006
Awai K, Xu C, Tamot B, Benning C. 2006. From the Cover: A phosphatidic acid-binding protein of the chloroplast inner envelope membrane involved in lipid trafficking. Proc Natl Acad Sci U S A. 2006 Jul 11;103(28):10817-22. Epub 2006 Jul 3. See PubMedCernac A, Andre C, Hoffmann-Benning S, Benning C. 2006. WRI1 is required for seed germination and seedling establishment. Plant Physiol. 2006 Jun;141(2):745-57. Epub 2006 Apr 21. See Pubmed
Xu C, Yu B, Cornish AJ, Froehlich JE, Benning C. 2006. Phosphatidylglycerol biosynthesis in chloroplasts of Arabidopsis mutants deficient in acyl-ACP glycerol-3- phosphate acyltransferase. Plant J. 2006 Jun 15; [Epub ahead of print] See PubMed
2005
Xu, C. Fan, J., Froehlich, J., Awai, K., and C. Benning. 2005. Mutation of the TGD1 chloroplast envelope protein affects phosphatidate metabolism in Arabidopsis. Plant Cell, 17: 3094-3110.See PubMedRiekhof, W.R., Andre, C., and C. Benning. 2005. Two Enzymes, BtaA and BtaB, are sufficient for betaine lipid biosynthesis in bacteria. Arch. Biochem. Biophys. 441:96-105. See PubMed
Barbier, G, Oesterhelt, C. Larson, M.D., Halgren, R.G., Wilkerson, C., Garavito, R.M., Benning, C., and A.P.M. Weber. 2005. Comparative genomics of two closely related unicellular thermo-acidophilic red algae, Galdieria sulphuraria and Cyanidioschyzon merolae, reveals the molecular basis of the metabolic flexibility of G. sulphuraria and significant differences in carbohydrate metabolism of both algae. Plant Phys.: 137:460-74. See PubMed
Shimojima M., Hoffmann-Benning, S. Garavito RM, Benning C. 2005. Ferredoxin-dependent glutamate sythase moonlights in plant sulfolipid biosynthesis forming a complex with SQD1. Arch. Biochem. Biophys.436:206-14. See PubMed
Riekhof, W., Sears B.B., and C. Benning. 2005. Annotation of genes involved in glycerolipid biosynthesis in Chlamydomonas reinhardtii: Discovery of betaine lipid synthase CrBTA1. Euk. Cell 4: 242-252. See PubMed
Wakao, S and C. Benning. 2005. Genome-wide analysis of glucose-6-phosphate dehydrogenases in Arabidopsis. Plant J. 41: 243-256. See PubMed
2004
Cernac, A. and C. Benning. 2004. WRINKLED1 encodes an AP2/EREB domain protein involved in the control of storage compound biosynthesis in Arabidopsis. Plant J. 40: 575-585. See PubMedWeber, A.P.M., Oesterhelt, C., Gross, W., Brautigam, A., Imboden, L.A., Krassakova, I., Linka, N., Truchina, J., Schneidereit, J., Voll, H., Voll, L.M., Zimmermann, M., Jamai, A., Riekhof, W.R., Yu, B., Graravito, R.M., and C. Benning. 2004. EST-analysis of the thermo-acidophilic red microalga Galdieria sulphuraria, reveals potential for lipid A biosynthesis and unveils the pathway of carbon export from chloroplasts. Plant Mol. Biol., 55: 17-32. See PubMed
Yu, B., Wakao S., Fan, J., and C. Benning. 2004. Loss of plastidic lysophosphatidic acid acyltransferase causes embryo-lethality in Arabidopsis. Plant Cell Physiol. 45:503-510. See PubMed
Yu, B. and C. Benning. 2003. Anionic lipids are required for chloroplast structure and function in Arabidopsis. Plant J., 36:762-770. See PubMed
2003
Riekhof, W.R., Ruckle, M.E., Lydic, T.A., Sears, B.B., and C. Benning. 2003. The sulfolipid 2'-O-acylsulfoquinovosyldiacylglcyerol and sulfoquinovosyldiacylglycerol are absent from a Chlamydomonas reinhardtii mutant deleted in SQD1. Plant Physiol., 133:864-874. See PubMedXu, C., Fan, J., Riekhof, W., Froehlich, J.E. and C. Benning. 2003. A permease-like protein involved in ER-to-thylakoid lipid transfer in Arabidopsis. EMBO J., 22:2370-2379. See PubMed
Shimojima, M. and C. Benning. 2003. Native uridine 5'-diphosphate sulfoquinovose synthase, SQD1, from spinach purifies as a 250-kDa complex. Arch. Biochem. Biophys. 413: 123-130. See PubMed
2002
Ruuska, S.A., Girke, T., Benning, C., and J.B. Ohlrogge. 2002. Contrapuntal networks of gene expression during Arabidopsis seed filling. Plant Cell 14: 1191-1206. See PubMedXu, C., Härtel, H., Wada, H., Hagio, M., Yu, B., Eakin, C., and C. Benning. 2002. The pgp1 mutant locus of Arabidopsis encodes a phosphatidyl-glycerolphosphate synthase with impaired activity. Plant Physiol. 129: 594-604. See PubMed
Yu, B., Xu, C., and C. Benning. 2002. Arabidopsis disrupted in SQD2 encoding sulfolipid synthase is impaired in phosphate-limited growth. Proc. Natl. Acad. Sci. USA 99:5732-5737. See PubMed
Klaus, D., Härtel, H., Fitzpatrick, L., Froehlich, J., Hubert, J., Benning, C., and P. Dörmann. 2002. Digalactosyldiacylglcyerol synthesis in chloroplasts of the Arabidopsis dgd1 mutant. Plant Physiol. 128:885-895. See PubMed
2001
Froehlich, J.E., Benning, C. and P. Dörmann. 2001. The digalactosyldiacylglycerol (DGDG) synthase DGD1 is inserted into the outer envelope membrane of chloroplasts in a manner independent of the general import pathway and does not depend on direct interaction with monogalactosyldiacylglycerol synthase for DGDG biosynthesis. J. Biol. Chem. 276: 31806-31812. See PubMedHärtel, H., Dörmann, P., and C. Benning. 2001. Galactolipids not associated with the photosynthetic apparatus in phosphate-deprived plants. J. Photochem. Photobiol B: Biol. 61: 46-51. See PubMed
Klug, R.M. and C. Benning. 2001. Two enzymes of diacylglyceryl-O-4'-(N,N,N,-trimethyl)-homoserine biosynthesis are encoded by btaA and btaB in the purple bacterium Rhodobacter sphaeroides. Proc. Natl. Acad. Sci. USA., 98: 5910-5915. See PubMed
Sanda, S., Leustek, T. Theisen, M.J., Garavito, R.M. and C. Benning. 2001. Recombinant Arabidopsis SQD1 converts UDP-glucose and sulfite to the sulfolipid head group precursor UDP-sulfoquinovose in vitro. J. Biol. Chem. 276: 3941-3946. See PubMed
2000
Dörmann, P., Gopalan, S., He, S.-H. and C. Benning. 2000. A gene family in Arabidopsis thaliana with sequence similarity to NDR1 and HIN1. Plant Phys. Biochem. 38: 789-796.Girke, T., Todd, J., Ruuska, S., White, J., Benning, C., and J. Ohlrogge. 2000. Microarray analysis of developing Arabidopsis seeds. Plant Physiol. 124: 1570-1581. See PubMed
White, J.A, Todd, J. Newman, T., Focks, N., Girke, T., Martinez de Ilarduya, O., Jaworski, J.G., Ohlrogge, J., and C. Benning. 2000. A new set of Arabidopsis expressed sequence tags from developing seeds. The metabolic pathway from carbohydrates to seed oil. Plant Physiol. 124: 1582-1594. See PubMed
Härtel, H., Dörmann, P., and C. Benning. 2000. DGD1-independent biosynthesis of extraplastidic galactolipids after phosphate deprivation in Arabidopsis. Proc. Natl. Acad. Sci. USA 97: 10649-10654. See PubMed
Jarvis, P., Dörmann, P., Peto, C.A., Lutes, J., Benning, C., and J. Chory. 2000. Galactolipid deficiency and abnormal chloroplast development in the Arabidopsis MGD synthase 1 mutant. Proc. Natl. Acad. Sci. USA 97: 8175-8179. See PubMed
Weissenmayer, B., Geiger, O., and C. Benning. 2000. Disruption of a gene essential for sulfoquinovosyl diacylglycerol biosynthesis in Sinorhizobium meliloti has no detectable effect on root nodule symbiosis. Mol. Plant Microbe. Interact. 13: 666-672. See PubMed
Güler, S., Essigmann, B., and C. Benning. 2000. A cyanobacterial gene, sqdX, required for biosynthesis of the sulfolipid sulfoquinovosyldiacylglycerol. J. Bacteriol. 182: 543-545. See PubMed
1999
Routaboul, J.-M., Benning, C., Bechtold, N., Caboche, M., and L. Lepiniec. 1999. The TAG1 locus of Arabidopsis encodes for a diacylglycerol acyltransferase. Plant Physiol. Biochem. 37: 831-840. See PubMedDörmann, P., Balbo, I., and C. Benning. 1999. Arabidopsis galactolipid biosynthesis and lipid trafficking mediated by DGD1. Science 284: 2181-2184. See PubMed
Mulichak, A.M., Theisen, M.J., Essigmann, B., Benning, C., and M. Garavito. 1999. Crystal structure of SQD1, an enzyme involved in the biosynthesis of the plant sulfolipid headgroup donor UDP-Sulfoquinovose. Proc. Natl. Acad. Sci. U.S.A. 96: 13097-13102. See PubMed
Essigmann, B., Hespenheide, B.M. Kuhn, L.A., and C. Benning. 1999. Prediction of the active-site structure and NAD+ binding in SQD1, a protein essential for sulfolipid biosynthesis in Arabidopsis. Arch. Biochem. Biophys. 369: 30-41. See PubMed
Focks, N., Sagasser, M., Weisshaar, B., and C. Benning. 1999. Charatcerization of tt15, a novel TRANPARENT TESTA mutant of Arabidopsis thaliana. Planta 208: 352-357. See Pubmed
Härtel, H., Essigmann, B., Lokstein, H., Hoffmann-Benning, S., Peters-Kottig, M., and C. Benning. 1998. The phospholipid-deficient pho1 mutant of Arabidopsis thaliana is affected in the organization, but not in the light acclimation, of the thylakoid membrane. Biochim. Biophys. Acta 1415: 205-218. See PubMed
1998
Focks, N., and C. Benning. 1998. A novel low oil mutant of Arabidopsis, wrinkled1, with a deficiency in the seed-specific regulation of carbohydrate metabolism. Plant Physiol. 118: 91-101. See PubMedEssigmann, B., Güler, S., Narang, R.A., Linke, D., and C. Benning. 1998. Phosphate availability affects the thylakoid lipid composition and the expression of SQD1, a gene required for sulfolipid biosynthesis in Arabidopsis thaliana. Proc. Natl. Acad. Sci. USA 95: 1950-1955. See PubMed
Härtel, H., Lokstein, H., Dörmann, P., Trethewey, R.N., and C. Benning. 1998. Photosynthetic light utilization and xanthophyll cycle activity in the galactolipid deficient dgd1 mutant of Arabidopsis thaliana. Plant Physiol. Biochem. 36: 407-417.
Dörmann, P., and C. Benning. 1998. The role of UDP-glucose epimerase in carbohydrate metabolism of Arabidopsis. Plant Journal 13: 641-652. See Pubmed
1997
Härtel, H., Lokstein, H., Dörmann, P., Grimm, B., and C. Benning. 1997. Changes in the composition of the photosynthetic apparatus in the galactolipid deficient dgd1 mutant of Arabidopsis thaliana. Plant Physiol. 115: 1175-1184. See PubMedReifarth, F., Christen, G., Seeliger, A.G., Dörmann, P., Benning, C., and G. Renger. 1997. Modification of the water oxidizing complex in leaves of the dgd1 mutant of Arabidopsis thaliana deficient in the galactolipid digalactosyldiacylglycerol. Biochemistry 36: 11769-11776. See Pubmed
Rossak, M., Schäfer, A., Xu, N., Gage, D. A., and C. Benning. 1997. Accumulation of sulfoquinovosyl-1-O-dihydroxyacetone in a sulfolipid-deficient mutant of Rhodobacter sphaeroides inactivated in sqdC. Arch. Biochem. Biophys. 340: 219-230. See PubMed
1996
Dörmann, P., and C. Benning. 1996. Functional expression of UDP-4-glucose-epimerase (EC 5.1.3.2) of Arabidopsis thaliana in yeast and Escherichia coli, Arch. Biochem. Biophys. 327: 27-34. See Pubmed1995
Güler, S., Seeliger, A., Härtel, H., Renger, G., and C. Benning. 1995. A null-mutant of Synechococcus sp. PCC7942 deficient in the sulfolipid sulfoquinovosyl diacylglycerol; J. Biol. Chem. 271: 7501-7507. See PubMedRossak, M., Tietje, C., Heinz., E., and C. Benning. 1995. Accumulation of UDP-sulfoquinovose in a sulfolipid-deficient mutant of Rhodobacter sphaeroides. J. Biol. Chem.270: 25792-25797. See PubMed
Dörmann, P., Hoffmann-Benning, S., Balbo, I., and C. Benning. 1995. Isolation and characterization of an Arabidopsis thaliana mutant deficient in the thylakoid lipid digalactosyl diacylglycerol. Plant Cell 7: 1801-1810. See PubMed
Benning, C., Huang, Z.-H., and A. A. Gage. 1995. Accumulation of a novel glyco- and betaine lipid in cells of Rhodobacter sphaeroides grown under phosphate-limitation. Arch. Biochem. Biophys. 317: 103-111. See PubMed
1993
Arondel, V., Benning, C. and C. R. Somerville. 1993. Isolation and functional expression in Escherichia coli of a gene encoding phosphatidylethanolamine methyl transferase ( EC 2.1.1.17) from Rhodobacter sphaeroides. J. Biol. Chem. 268: 16002-16008.Benning, C., Beatty, T. Prince, R. C. and C. R. Somerville. 1993. The sulfolipid sulfoquinovosyldiacylglycerol is not required for photosynthetic electron transport in Rhodobacter sphaeroides but enhances growth under phosphate limitation. Proc. Natl. Acad. Sci. USA 90: 1561-1565.
1992
Benning, C., and C. R. Somerville. 1992. Identification of an operon involved in sulfolipid biosynthesis in Rhodobacter sphaeroides. J. Bacteriol. 174: 6479-6487.Benning, C. and C. R. Somerville. 1992. Isolation and genetic complementation of a sulfolipid-deficient mutant of Rhodobacter sphaeroides. J. Bacteriol. 174: 2352-2360.
Bohmert, K., Camus, I., Bellini, C., Bouchez, D., Caboche, M, and C. Benning. 1998. AGO1 defines a novel locus of Arabidopsis controlling leaf development. EMBO J. 17: 170-180.
Gage, D. H., Huang, Z. H. and C. Benning. 1992. Comparison of sulfoquinovosyl diacylglycerol from spinach and the purple bacterium Rhodobacter sphaeroides by fast atom bombardment tandem mass spectrometry. Lipids 27: 632-636.