Recent Publications

Mulabagal V, Subbaraju GV, Rao CV, Sivaramakrishna C, Dewitt DL, Holmes D, Sung B, Aggarwal BB, Tsay HS, Nair MG. Withanolide sulfoxide from Aswagandha roots inhibits nuclear transcription factor-kappa-B, cyclooxygenase and tumor cell proliferation. Phytother Res. 2009 Jul;23(7):987-92.

Mulabagal V, Lang GA, DeWitt DL, Dalavoy SS, Nair MG. Anthocyanin content, lipid peroxidation and cyclooxygenase enzyme inhibitory activities of sweet and sour cherries. J Agric Food Chem. 2009 Feb 25;57(4):1239-46.

Mulabagal V, Alexander-Lindo RL, Dewitt DL, Nair MG. Health-Beneficial Phenolic Aldehyde in Antigonon leptopus Tea. Evid Based Complement Alternat Med. 2009 May 19.

V Mulabagal, GA Lang, DL DeWitt, SS Dalavoy, MG Nair: Anthocyanin content, lipid peroxidation and cyclooxygenase enzyme inhibitory activities of sweet and sour cherries. J. Agric. Food Chem. ( Feb 25 2009) 57 1239-1246.

Raman P, Dewitt DL, Nair MG. Lipid peroxidation and cyclooxygenase enzyme inhibitory activities of acidic aqueous extracts of some dietary supplements. Phytother Res. 2008 Feb;22(2):204-12.

Mulabagal V, Van Nocker S, Dewitt DL, Nair MG. Cultivars of apple fruits that are not marketed with potential for anthocyanin production. J Agric Food Chem. 2007 Oct 3;55(20):8165-9.

Cuendet M, Mesecar AD, DeWitt DL, Pezzuto JM. An ELISA method to measure inhibition of the COX enzymes. Nat Protoc. 2006;1(4):1915-21.

Mbonye UR, Wada M, Rieke CJ, et al. The 19-amino acid cassette of cyclooxygenase-2 mediates entry of the protein into the endoplasmic reticulum-associated degradation system Journal of Biological Chemistry 281 (47): 35770-35778 Nov 24 2006.

MirAfzali Z, Leipprandt JR, McCracken JL, et al. Topography of the prostaglandin endoperoxide H-2 synthase-2 in membranes Journal of Biological Chemistry 281 (38): 28354-28364 Sep 22 2006.

Adhikari DP, Schutzki RE, DeWitt DL, et al. Effects of Amelanchier fruit isolates on cyclooxygenase enzymes and lipid peroxidation Food Chemistry 97 (1): 56-64 Jul 2006.

Jankun J, Aleem AM, Malgorzewicz S, et al. Synthetic curcuminoids modulate the arachidonic acid metabolism of human platelet 12-lipoxygenase and reduce sprout formation of human endothelial cells Molecular Cancer Thearpeutics 5 (5): 1371-1382 May 2006.

MirAfzali Z, Leipprandt JR, McCracken JL, DeWitt DL. Fast, efficient reconstitution of the cyclooxygenases into proteoliposomes. Arch Biochem Biophys. 2005 Nov 15;443(1-2):60-5. Epub 2005 Sep 15.

Zhang Y, Dewitt DL, Murugesan S, Nair MG. Cyclooxygenase-2 enzyme inhibitory triterpenoids from Picrorhiza kurroa seeds. Life Sci. 2005 Nov 4;77(25):3222-30. Epub 2005 Jun 23.

Garavito RM, Malkowski MG, DeWitt DL. The structures of prostaglandin endoperoxide H synthases-1 and -2. Prostaglandins Other Lipid Mediat. 69:129-152 (2002)

Proshlyakov, D.A., Pressler, M.A., DeMaso, C., Leykam, J.F., Dewitt, D.L. and Babcock, G.T. The missing link in cytochrome oxidase: Y₂₄₄ is redox-active in O₂ activation and reduction. Science. 290:1588-1591 (2000).

Smith, T., Leipprandt, J., and D. L. DeWitt. Purification and Characterization of the Human Recombinant Histidine-Tagged Prostaglandin Endoperoxide H Synthases -1 and -2. Arch. Biochem. 375 :195-200,2000.

Wang, H., Nair, M.G., Strasburg, G.M., Booren, A. M., Gray, I., and D. L. DeWitt. Cyclooxygenase active bioflavonoids from Balaton tart cherry and their structure activity relationships. Phytomed. 7:15-19, 2000.

Kelm, M. A, Nair, M. G. , Strasburg, G. M., and D. L. DeWitt. Antioxidant and cyclooxygenase inhibitory phenolic compound from Ocimum sanctum Linn. Phytomed. 7:7-13, 2000.

Blanco, J.C. Countusi, C. , Salkowski, C.A., DeWitt, D. L., Ozato, K. and S.N. Vogel. Interferon regulatory factor (IRF-1) and IRF-2 regulate IFN-(-dependent cyclooxygenase 2 (Cox-2) expression. J. Exp. Med. 191:2131-2144, 2000.

Ramsewak RS, DeWitt DL, Nair MG. Cytotoxicity, antioxidant and anti-inflammatory activities of curcumins I-III from Curcuma longa. Phytomed. 7:303-8, 2000.

Smith, W.L., DeWitt, D.L. and R.M. Garavito. Cyclooxygenases: Structural, Cellular and Molecular Biology. In: Annu. Rev. Biochem. 69:146-182, 2000.

DeWitt, D.L. Cox-2 Selective Inhibitors - The New Super Aspirins. Mol. Pharm. 4:625-631, 1999.

Bansewak, R.S., Muraleedharan, Nair, M.G., Strasburg, G.M., DeWitt, D. L., and J.L. Nitiss. Biologically Active carbazole Alkaloids from Murraya koeniggii. J. Agric. F. Chem. 47:444-447, 1999.

Wang, H., Muraleedharan, Nair, M.G., Strasburg, G.M., Chang, Y., Booren, A.M., Gray, I. J., and D. L. DeWitt. Antioxidant and Antiinflammatory Activities of Anthocyanins and Their Aglycon, Cyanidin, from Tart Cherries. J. Nat. Prod. 62:294-296, 1999.

Garavito, R.M and D. L. DeWitt. The cyclooxygenase isoformsstructural insights into the conversion of arachidonic to prostaglandins. BBA. 55528 :1-10, 1999.

Ramseqak, R.S., Nair, M. G., DeWitt, D. L, Matttson, W. G., and J. Zasada. Phenolic glycosides from Dirca palustris. J. Nat Prod. 62: 1558-1561, 1999.

Spencer, A.G., Thuresson, E. Otto, J. C., Song, I., Smith, T., DeWitt, D. L., Garavito, R.M., and W. L. Smith. The membrane binding domains of prostaglandin endoperoxide H synthases-1 and -2Peptide mapping and mutational analysis. J. Biol. Chem. 274:32936-32942, 1999.D. L. DeWitt. Cyclooxygenases in Health and Disease. Gastro. Int. 12:157-169, 1999.

Li, Y., Smith, T. , and D. L. DeWitt. The Membrane Association Sequences of the Prostaglandin Endoperoxide Synthases -1 and -2 Isozymes. J Biol. Chem. 273:29830-29837, 1998.

Dewitt home page