David L. DeWitt
Professor
Assoc Dean - CNS
Director - RTSF

• B.S. 1976, University of California, Davis
• Ph.D. 1982, Michigan State University
• Postdoctoral Fellow, 1982-85, La Jolla Cancer Research Foundation

dewittd@msu.edu
519A Biochemistry Building
Michigan State University
East Lansing, MI 48824-1319
Office: 517-353-5284
Lab: 517-432-2141


Publication search:

Recent Publications

Raman P, Dewitt DL, Nair MG. Lipid peroxidation and cyclooxygenase enzyme inhibitory activities of acidic aqueous extracts of some dietary supplements. Phytother Res. 2008 Feb;22(2):204-12.

Mulabagal V, Van Nocker S, Dewitt DL, Nair MG. Cultivars of apple fruits that are not marketed with potential for anthocyanin production. J Agric Food Chem. 2007 Oct 3;55(20):8165-9.

Cuendet M, Mesecar AD, DeWitt DL, Pezzuto JM. An ELISA method to measure inhibition of the COX enzymes. Nat Protoc. 2006;1(4):1915-21.

Mbonye UR, Wada M, Rieke CJ, et al. The 19-amino acid cassette of cyclooxygenase-2 mediates entry of the protein into the endoplasmic reticulum-associated degradation system Journal of Biological Chemistry 281 (47): 35770-35778 Nov 24 2006.

MirAfzali Z, Leipprandt JR, McCracken JL, et al. Topography of the prostaglandin endoperoxide H-2 synthase-2 in membranes Journal of Biological Chemistry 281 (38): 28354-28364 Sep 22 2006.

Adhikari DP, Schutzki RE, DeWitt DL, et al. Effects of Amelanchier fruit isolates on cyclooxygenase enzymes and lipid peroxidation Food Chemistry 97 (1): 56-64 Jul 2006.

Jankun J, Aleem AM, Malgorzewicz S, et al. Synthetic curcuminoids modulate the arachidonic acid metabolism of human platelet 12-lipoxygenase and reduce sprout formation of human endothelial cells Molecular Cancer Thearpeutics 5 (5): 1371-1382 May 2006.

MirAfzali Z, Leipprandt JR, McCracken JL, DeWitt DL. Fast, efficient reconstitution of the cyclooxygenases into proteoliposomes. Arch Biochem Biophys. 2005 Nov 15;443(1-2):60-5. Epub 2005 Sep 15.

Zhang Y, Dewitt DL, Murugesan S, Nair MG. Cyclooxygenase-2 enzyme inhibitory triterpenoids from Picrorhiza kurroa seeds. Life Sci. 2005 Nov 4;77(25):3222-30. Epub 2005 Jun 23.

Garavito RM, Malkowski MG, DeWitt DL. The structures of prostaglandin endoperoxide H synthases-1 and -2. Prostaglandins Other Lipid Mediat. 69:129-152 (2002)

Proshlyakov, D.A., Pressler, M.A., DeMaso, C., Leykam, J.F., Dewitt, D.L. and Babcock, G.T. The missing link in cytochrome oxidase: Y₂₄₄ is redox-active in O₂ activation and reduction. Science. 290:1588-1591 (2000).

Smith, T., Leipprandt, J., and D. L. DeWitt. Purification and Characterization of the Human Recombinant Histidine-Tagged Prostaglandin Endoperoxide H Synthases -1 and -2. Arch. Biochem. 375 :195-200,2000.

Wang, H., Nair, M.G., Strasburg, G.M., Booren, A. M., Gray, I., and D. L. DeWitt. Cyclooxygenase active bioflavonoids from Balaton tart cherry and their structure activity relationships. Phytomed. 7:15-19, 2000.

Kelm, M. A, Nair, M. G. , Strasburg, G. M., and D. L. DeWitt. Antioxidant and cyclooxygenase inhibitory phenolic compound from Ocimum sanctum Linn. Phytomed. 7:7-13, 2000.

Blanco, J.C. Countusi, C. , Salkowski, C.A., DeWitt, D. L., Ozato, K. and S.N. Vogel. Interferon regulatory factor (IRF-1) and IRF-2 regulate IFN-(-dependent cyclooxygenase 2 (Cox-2) expression. J. Exp. Med. 191:2131-2144, 2000.

Ramsewak RS, DeWitt DL, Nair MG. Cytotoxicity, antioxidant and anti-inflammatory activities of curcumins I-III from Curcuma longa. Phytomed. 7:303-8, 2000.

Smith, W.L., DeWitt, D.L. and R.M. Garavito. Cyclooxygenases: Structural, Cellular and Molecular Biology. In: Annu. Rev. Biochem. 69:146-182, 2000.

DeWitt, D.L. Cox-2 Selective Inhibitors - The New Super Aspirins. Mol. Pharm. 4:625-631, 1999.

Bansewak, R.S., Muraleedharan, Nair, M.G., Strasburg, G.M., DeWitt, D. L., and J.L. Nitiss. Biologically Active carbazole Alkaloids from Murraya koeniggii. J. Agric. F. Chem. 47:444-447, 1999.

Wang, H., Muraleedharan, Nair, M.G., Strasburg, G.M., Chang, Y., Booren, A.M., Gray, I. J., and D. L. DeWitt. Antioxidant and Antiinflammatory Activities of Anthocyanins and Their Aglycon, Cyanidin, from Tart Cherries. J. Nat. Prod. 62:294-296, 1999.

Garavito, R.M and D. L. DeWitt. The cyclooxygenase isoformsstructural insights into the conversion of arachidonic to prostaglandins. BBA. 55528 :1-10, 1999.

Ramseqak, R.S., Nair, M. G., DeWitt, D. L, Matttson, W. G., and J. Zasada. Phenolic glycosides from Dirca palustris. J. Nat Prod. 62: 1558-1561, 1999.

Spencer, A.G., Thuresson, E. Otto, J. C., Song, I., Smith, T., DeWitt, D. L., Garavito, R.M., and W. L. Smith. The membrane binding domains of prostaglandin endoperoxide H synthases-1 and -2Peptide mapping and mutational analysis. J. Biol. Chem. 274:32936-32942, 1999.D. L. DeWitt. Cyclooxygenases in Health and Disease. Gastro. Int. 12:157-169, 1999.

Li, Y., Smith, T. , and D. L. DeWitt. The Membrane Association Sequences of the Prostaglandin Endoperoxide Synthases -1 and -2 Isozymes. J Biol. Chem. 273:29830-29837, 1998.

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