Shelagh Ferguson-Miller Recent Publications
Qin L, Liu J, Mills DA, Proshlyakov DA, Hiser C, Ferguson-Miller S. Redox-dependent conformational changes in cytochrome C oxidase suggest a gating mechanism for proton uptake. Biochemistry. 2009 Jun 16;48(23):5121-30.
Zhang X, Ferguson-Miller SM, Reid GE. Characterization of ornithine and glutamine lipids extracted from cell membranes of Rhodobacter sphaeroides. J Am Soc Mass Spectrom. 2009 Feb;20(2):198-212.
Sharpe MA, Krzyaniak MD, Xu S, McCracken J, Ferguson-Miller S. EPR evidence of cyanide binding to the Mn(Mg) center of cytochrome c oxidase: support for Cu(A)-Mg involvement in proton pumping. Biochemistry. 2009 Jan 20;48(2):328-35.
Mills DA, Xu S, Geren L, Hiser C, Qin L, Sharpe MA, McCracken J, Durham B, Millett F, Ferguson-Miller S. Proton-dependent electron transfer from CuA to heme a and altered EPR spectra in mutants close to heme a of cytochrome oxidase. Biochemistry. 2008 Nov 4;47(44):11499-509.
Sharpe MA, Ferguson-Miller S. A chemically explicit model for the mechanism of proton pumping in heme-copper oxidases. J Bioenerg Biomembr. 2008 Oct;40(5):541-9.
Qin L, Mills DA, Buhrow L, Hiser C, Ferguson-Miller S. A conserved steroid binding site in cytochrome C oxidase. Biochemistry. 2008 Sep 23;47(38):9931-3.
Qin L, Sharpe MA, Garavito RM, Ferguson-Miller S. Conserved lipid-binding sites in membrane proteins: a focus on cytochrome c oxidase. Curr Opin Struct Biol. 2007 Aug;17(4):444-50. Review.
Qin L, Mills DA, Hiser C, Murphree A, Garavito RM, Ferguson-Miller S, Hosler J. Crystallographic location and mutational analysis of Zn and Cd inhibitory sites and role of lipidic carboxylates in rescuing proton path mutants in cytochrome c oxidase. Biochemistry. 2007 May 29;46(21):6239-48.
Xu J, Sharpe MA, Qin L, Ferguson-Miller S, Voth GA. (2007) Storage of an excess proton in the hydrogen-bonded network of the d-pathway of cytochrome C oxidase: identification of a protonated water cluster. J Am Chem Soc. 129(10):2910-3.
Qin L, Hiser C, Mulichak A, Garavito RM, Ferguson-Miller S. (2006) Identification of conserved lipid/detergent-binding sites in a high-resolution structure of the membrane protein cytochrome c oxidase. Proc Natl Acad Sci U S A. 103(44):16117-22.
Hosler JP, Ferguson-Miller S, Mills DA. (2006) Energy transduction: proton transfer through the respiratory complexes. Annu Rev Biochem. 75:165-87.
Seibold SA, Mills DA, Ferguson-Miller S, Cukier RI. (2005) Water chain formation and possible proton pumping routes in Rhodobacter sphaeroides cytochrome c oxidase: a molecular dynamics comparison of the wild type and R481K mutant. Biochemistry. 44(31):10475-85.
Branden G, Branden M, Schmidt B, Mills DA, Ferguson-Miller S, Brzezinski P. (2005) The protonation state of a heme propionate controls electron transfer in cytochrome c oxidase. Biochemistry. 44(31):10466-74.
Mills DA, Geren L, Hiser C, Schmidt B, Durham B, Millett F, Ferguson-Miller S. (2005) An arginine to lysine mutation in the vicinity of the heme propionates affects the redox potentials of the hemes and associated electron and proton transfer in cytochrome c oxidase. Biochemistry. 44(31):10457-65.
Qian J, Mills DA, Geren L, Wang K, Hoganson CW, Schmidt B, Hiser C, Babcock GT, Durham B, Millett F, Ferguson-Miller S. (2004) Role of the conserved arginine pair in proton and electron transfer in cytochrome C oxidase. Biochemistry 43(19):5748-56.
Distler AM, Allison J, Hiser C, Qin L, Hilmi Y, Ferguson-Miller S.(2004) Mass spectrometric detection of protein, lipid and heme components of cytochrome c oxidase from R. sphaeroides and the stabilization of non-covalent complexes from the enzyme. Eur J Mass Spectrom (Chichester, Eng) 10(2):295-308.
Schmidt B, Hillier W, McCracken J, Ferguson-Miller S. (2004) The use of stable isotopes and spectroscopy to investigate the energy transducing function of cytochrome c oxidase. Biochim Biophys Acta 2004 Apr 12;1655(1-3):248-55.
Schmidt B, McCracken J, Ferguson-Miller S. (2003) A discrete water exit pathway in the membrane protein cytochrome c oxidase. Proc Natl Acad Sci U S A Epub 2003 Dec 05. Dec 23;100(26):15539-42.
Mills DA, Tan Z, Ferguson-Miller S, Hosler J. (2003) A role for subunit III in proton uptake into the D pathway and a possible proton exit pathway in Rhodobacter sphaeroides cytochrome c oxidase. Biochemistry Jun 24;42(24):7410-7.
Mills DA, Ferguson-Miller S. (2003) Understanding the mechanism of proton movement linked to oxygen reduction in cytochrome c oxidase: lessons from other proteins. FEBS Lett Jun 12;545(1):47-51.
Newmeyer DD, Ferguson-Miller S. (2003) Mitochondria: releasing power for life and unleashing the machineries of death. Cell Feb 21;112(4):481-90.
Pawate AS, Morgan J, Namslauer A, Mills D, Brzezinski P, Ferguson-Miller S, Gennis RB. (2002) A mutation in subunit I of cytochrome oxidase from Rhodobacter sphaeroides r esults in an increase in steady-state activity but completely eliminates proton pumping. Biochemistry Nov 12;41(45):13417-23.
Mills DA, Ferguson-Miller S. (2002) Influence of structure, pH and membrane potential on proton movement in cytochrome oxidase. Biochim Biophys Acta 1555(1-3):96-100.