Pamela J. Fraker Recent Publications
Trottier, M., Newstad, M., King, L. and Fraker,P. (2008) Natural glucocorticoids induce expansion of all developmental stages of murine bone marrow granulocytes without inhibiting function. (Accepted PNAS)
Claycombe, K., King, L., and Fraker, P. (2008) A role for leptin in sustaining lymphopoiesis and myelopoiesis. (Accepted PNAS)
King LE, Frentzel JW, Mann JJ, Fraker PJ. (2005) Chronic zinc deficiency in mice disrupted T cell lymphopoiesis and erythropoiesis while B cell lymphopoiesis and myelopoiesis were maintained. Journal Of The American College Of Nutrition 24 (6): 494-502.
Mann, JJ and Fraker,PJ. (2005) Zinc pyrithione induces apoptosis and increases expression of Bim. Apoptosis. 10:369-379.
Fraker PJ. (2005) Roles for cell death in zinc deficiency. J Nutr. Mar;135(3):359-62.
Fraker PJ, King LE. (2004) Reprogramming of the immune system during zinc deficiency. Annu Rev Nutr.;24:277-98. Review.
Fraker PJ, Lill-Elghanian DA. (2004) The many roles of apoptosis in immunity as modified by aging and nutritional status. J Nutr Health Aging.;8(1):56-63. Review.
Huang ZL, Fraker PJ. (2003) Chronic consumption of a moderately low protein diet does not alter hematopoietic processes in young adult mice. J Nutr. May;133(5):1403-8.
Laakko T, Schwartz RC, Fraker PJ. (2002) IL-7-mediated protection of pro and pre-B cells from the adverse effects of corticosterone. Cell Immunol. Nov;220(1):39-50.
Islam Z, King LE, Fraker PJ, Pestka JJ. (2003) Differential induction of glucocorticoid-dependent apoptosis in murine lymphoid subpopulations in vivo following coexposure to lipopolysaccharide and vomitoxin (deoxynivalenol). Toxicol Appl Pharmacol. Mar 1;187(2):69-79.
King LE, Fraker PJ. (2002) Zinc deficiency in mice alters myelopoiesis and hematopoiesis. J Nutr. Nov;132(11):3301-7.
King LE, Osati-Ashtiani F, Fraker PJ. (2002) Apoptosis plays a distinct role in the loss of precursor lymphocytes during zinc deficiency in mice. J Nutr. May;132(5):974-9.
Islam Z, Moon YS, Zhou HR, King LE, Fraker PJ, Pestka JJ. (2002) Endotoxin potentiation of trichothecene-induced lymphocyte apoptosis is mediated by up-regulation of glucocorticoids. Toxicol Appl Pharmacol. Apr 1;180(1):43-55.
Fraker PJ, King LE. (2001) A distinct role for apoptosis in the changes in lymphopoiesis and myelopoiesis created by deficiencies in zinc. FASEB J. Dec;15(14):2572-8. Review.
King, L.E., Fraker, P.J. (2000) Variations in the cell cycle status of lymphopoietic and myelopoietic cells created by zinc deficiency. J. Infect Dis 182, 16-22.
Fraker, P.J., King, L.E., Laakko, T., Vollmer, T.L. (2000) The dynamic link between the integreity of the immune system and zinc status. J. Nutr. 130 1399-1406.
Lappin, P.B., Ross, K.L., King, L.E., Fraker, P.J., Roth, R.A. (1998) The response of pulmonary vascular endothelial cells to monocrotaline pyrro proliferation and DNA synthesis in vitro and in vivo. Toxicol. Appl. Pharmacol, 150, 37-48.
Telford, W. and Fraker, P. (1998) Zinc-induced apoptosis in bone marrow and splenic B-cells. Nutr. Research J. 18, 319-326.
Fraker, P. and King, L. (1998) Changes in regulation of lymphopoiesis and myelopoiesis in the zinc deficient mouse. Nutrition Reviews 56, 565-569.
Osati, F., King, L. and Fraker, P. (1998) Survival of pro B-cells in zinc deficient mice. Immunology 94, 94-100.
Fraker, P. and Telford, W. (1997) A reappraisal of the role of zinc in the life and death decision of life. Proc. Soc. Exp. Med. 215, 229-236.
Telford, W. and Fraker, P. (1997) Zinc reversibility inhibits steroid binding to the glucocorticoid receptor. Biochem. Biophys. Res. Commun. 238, 86-91.
Fraker, P. and Telford, W. (1996) Regulation of apoptotic events by zinc. In: Nutrition and Gene Expression (Berdanier, C., ed.), CRC Press, Boca Raton, FL, pp. 189-208.