R. Michael Garavito
Professor
- B.A. 1974, University of California, San Diego
- Ph.D. 1978, Purdue University
- Postdoctoral Fellow, 1979-82, Biocenter, University of Basel, Switzerland
- Independent Scientist, 1983-86, Biocenter, University of Basel, Switzerland
- Faculty Member, 1987-95, University of Chicago
513 Biochemistry Building
Michigan State University
East Lansing, MI 48824-1319
Office: 517-355-9724
Lab: 517-353-9125
FAX: 517-353-9334
Lab Home page
Current Projects
Publication search:
R. Michael Garavito Research Interests continued
Despite the differences in their physiological roles, the structures and catalytic functions of PGHS-1 and -2 are virtually identical. However, a handful of amino acid substitutions give rise to differences in ligand interactions between the isoforms. The structure-function relationships in PGHS isozymes are actively being studied in my laboratory, using X-ray diffraction and difference Fourier analysis. Our general goals are to determine the mechanisms for free radical catalysis involving PGHS, to develop models for free radical migration, and to determine fatty acid ligands and similar compounds can bind to PGHSs. We and our collaborators studying the functional consequences of subtle atomic alterations in structure using a combination of X-ray crystallography, molecular biology, resonance Raman spectroscopy, and EPR.
Full text of research interests