PGHS-1
Cyclooxygenase
PGHS-1 dimer showing the membrane interaction surface
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PGHS-1 dimer surface showing how the epidermal growth factor-like (EGF) domain and the membrane binding domain form the membrane interaction surface. References of Interest Picot, D., Loll, P. J., and Garavito, R. M. (1994) "The X-ray
crystal structure of the membrane protein prostaglandin H2
synthase-1." Nature (London) 367, 243-249. Loll, P. J., Picot, D., and Garavito, R. M. (1995) "The
structural basis of aspirin activity inferred from the crystal structure of
inactivated prostaglandin H2 synthase." Nature Structural Biology
2, 637-643. W. L. Smith, R. M. Garavito, D. L. DeWitt (1996) "Prostaglandin
endoperoxide H synthases (cyclooxygenases)-1 and 2." J. Biol.
Chem. 271, 33157-60. R. M. Garavito (1996) "The cyclooxygenase-2 structure: new
drugs for an old target?" Nature Struct. Biol. 3, 897-901. Garavito, R. M., and DeWitt, D. L. (1999) "The cyclooxygenase
isoforms: Structural insights into the conversion of arachidonic acid to
prostaglandins." Biochim. Biophys. Acta, 1441, 278-87. Malkowski, M.G., Ginell, S., Smith, W.L., and Garavito, R. M. (2000)
"Structure of prostaglandin synthase complexed with arachidonic
acid." Science 289,1933-37. Thuresson, E.D., Lakkides, K. M., Rieke, C.J., Sun, Y., Wingerd, B.,
Micielli, R. J., Mulichak, A. M., Malkowski, M. G., Garavito, R. M., Smith,
W.L. (2001) "Prostaglandin endoperoxide synthase-1: The functions of
cycloxygenase active site residues in the binding, positioning and
oxygenastion of arachidonic acid." J. Biol. Chem. 276, 10347-59. Thuresson, E.D,. Malkowski, M. G., Lakkides, K. M., Rieke, C.J., Mulichak,
A. M. , Ginell, S., Garavito, R. M., Smith, W.L. (2001) "Mutational and
X-ray crystallographic analysis of the interaction of homo-g-linolenic acid
with prostaglandin endoperoxide synthases." J. Biol. Chem. 276,
10358-65. M. G. Malkowski, E. D. Thuresson, K. M. Lakkides, C. J. Rieke, R.
Micielli, W. L. Smith, and R. M. Garavito (2001) Structure of
Eicosapentaenoic and Linoleic acids in the cyclooxygenase site of
prostaglandin endoperoxide H synthase-1. J. Biol. Chem. 276, 37547–37555. Lin, H. J., Lakkides, K. M., T. O. Keku, S. T. Reddy, A. D. Louie, I. H.
Kau, H. Zhou, et al. (2002) "Prostaglandin H synthase 2 variant in
African Americans may reduce the risk for colorectal neoplasia." Cancer
Epidemiology, Biomarkers, and Prevention 11, 1305-15. Malkowski, M. G., DeWitt, D. L., Garavito, R. M. (2002) "The
Structures of Prostaglandin Endoperoxide H Synthases-1 and -2".
Prostaglandins and other Lipid Mediators 68-69, 129-52. Garavito, R. M. and Mulichak, A. M. (2003) The structure of mammalian
cyclooxygenases. Annu. Rev. Biophys. Biomolec. Struct. 32, 183-206. Harman C., C. J. Rieke R. M. Garavito, and W. L. Smith. (2004) “Crystal
Structure of Arachidonic Acid Bound to a Mutant of Prostaglandin Endoperoxide
Synthase-1 that Forms Predominantly 11-HPETE.” J. Biol. Chem. 279, 42929 - 42935. |
