Hegg Lab Members
Principal Investigator |
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Eric Hegg |
I obtained my B.A. from Kalamazoo College and my Ph.D. from the University of Wisconsin under the direction of Professor Judith Burstyn. It was during my time at Wisconsin that I became interested in metalloenzymology, studying the role of metal ions in enzymes that hydrolyze DNA, RNA, and proteins. After receiving my Ph.D., I joined Larry Que's group at the University of Minnesota as an NIH postdoctoral fellow where I studied non-heme iron dioxygenases and established my long-standing interest in understanding how nature synthesizes and activates small molecules such as H2 and O2. Following my postdoctoral work, my family and I moved to Salt Lake City where I joined the faculty of the University of Utah and began my independent research career. When the opportunity arose, my wife and I eagerly returned to the northern Midwest to join the faculty at MSU. In addition to studying heme biosynthesis and O2 utilization, I am involved in developing renewable bioenergy, using phototrophic microbes to generate H2 from sunlight and water.
E-mail:EricHegg@msu.edu |
Research Associates |
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Vaidyanathan Mathrubootham ("Vaidy") received his PhD in 2000 from Bharathidasan University, India and moved to Drexel University, Philadelphia as an instructor/postdoc fellow where he enjoyed teaching undergraduates. In 2003 he moved to the University of Utah to work with Dr. Eric L. Hegg. Vaidy moved along with Dr. Hegg when the lab shifted to MSU in 2006. Vaidy has been involved in making synthetic and catalytic models for the nickel-containing enzymes CODH/ACS and Ni-SOD.
E-mail:vaidymm@msu.edu |
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Shipra Gupta is a Postdoctoral Research Associate in the Hegg lab. She joined the Department of Biochemistry and Molecular Biology in April, 2007. Dr. Gupta is working on the characterization of heme A synthase and its reaction mechanism. Prior to joining Dr. Hegg's lab, she did her first postdoctoral research at the International Center for Genetic Engineering and Biotechnology (ICGEB) from March 2006 to February 2007, Delhi (India). At ICGEB, she worked on CBL and CIPK, genes responsible for abiotic stress tolerance in plants. Shipra received her Master's (2001) and Ph.D. (2006) from the Department of Environmental Biology, University of Delhi, India. For her doctoral research work, she raised antibiotic marker-free codA transgencis of Brassica juncea cv. Varuna with improved antibiotic stress tolerance. She enjoys her research and looks at each experiment as a beginning of a new day. E-mail:sgupta79@msu.edu |
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Graduate Assistants | |
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Adam Cornish is a graduate research assistant in the Biochemistry Department. He joined the lab in February 2008. His current research goals are centered around [FeFe]-hydrogenases, enzymes that catalyze the reduction of protons and electrons to form molecular hydrogen. He is interested in the use of Shewanella oneidensis, a facultative soil bacterium, as a model system for heterologous expression of hydrogenases. Another area of interest lies in the use of degenerate primers to search for novel hydrogenases from hyperthermophilic organisms in environmental samples. Finally, he also wishes to investigate the pathways of electron and hydrogen transport through the enzyme. His interests include clean dishware, anaeorbic environments, and avoiding the fourth floor autoclave room. |
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Hui Yang is a graduate student in the Hegg lab. She joined the BMB department in 2007. She became a member of the Hegg lab in 2008. Her research is mainly about metabolic water and the use of metabolic water. Her projects are: (1) testing the oxygen source of metabolic water pool using oxygen isotopes; (2) investigating the proton flux during biological hydrogen production using hydrogen isotopes. She likes research and science. However, she also likes cartoons a lot. |
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Emily Harper is a graduate student in the Cell and Molecular Biology Program. She joined the Hegg lab in May 2008. Before coming to Michigan State she obtained her undergraduate degree from Hope College in Holland, MI. The goal of her research is to identify how heme A is inserted into subunit 1 of cytochrome c oxidase and to identify the protein complexes that are formed during this process. A second part of her project is to identify the transcription factors that regulate heme A synthase. Previous work in the lab has identified Hap1 as being one such transcription factor for heme A synthase but has also suggested the possibility that another transcription factor is involved in the regulation of heme A synthase. Emily's work will seek to identify this second transcription factor. Other interests include summer weekends at Lake Michigan, hiking, and chocolate ice-cream. |
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Yuxin Wang is a graduate student in the Master's Degree Program in Industrial Microbiology. Before beginning her graduate studies at MSU she worked as a technician in the Hegg lab in August of 2007. She received her B.S. in Biochemistry and M.S. in Genetics in China. Her work in the lab is studying heme biosynthesis, transport, and regulation. |
Undergraduate Students | |
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Jason Thomas is a physiology major and he is working with Vaidy on synthetic modeling of nickel-containing enzymes, CODH/ACS and Ni-SOD. Jason is part of the Professorial Assistantship program at Michigan State University. He joined the Hegg lab in the Fall of 2007, and he plans on continuing with this lab until he graduates. Jason likes to play sports and stay active. He also enjoys hanging out with friends. E-mail:thoma615@msu.edu |
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Saundra Hempel recently finished her bachelor's degree in Biochemistry and Molecular Biology in May 2009 and is currently working with Adam Cornish. Her research interests include molecular cloning of hydrogenases into vectors for expression in Eschericia coli and Shewenella oneidensis. Her experiences in the lab have left her well-equipped to approach problems from multiple angles and to develop her own experiments. When not working in the lab, she enjoys visiting the local Beaner's and supporting varied causes in the area. |
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Robin Green is a sophomore professorial assistant working with Katrin Gaertner and is just starting his bachelor's degree in Biochemistry and Molecular Biology. His enthusiasm and passion for the work can be seen in everything he does. Outside of the lab, he enjoys studying, reading, and spending time with his new college friends. |
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Jason Siebert is a freshman professorial assistant working with Shipra Gupta and Emily Harper on the Heme project. Currently he plans to major in Biochemistry and Molecular Biology. In his free time, Jason enjoys various sports such as snowboarding and soccer. E-mail:sieber10@msu.edu |
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Michael Zhang is a freshman assistant working with Shipra Gupta on the Heme project. Currently he hopes on attending medical school with a major in human biology. During his free time Mike enjoys sports either on TV or playing them. His favorite sports are basketball and football. He also enjoys hanging out with friends and going on road trips. |
Combining
work and fun
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Previous Hegg Lab Members
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