Eric L. Hegg
Associate Professor
- B.A. Kalamazoo College, 1991
- Ph.D. University of Wisconsin, 1996
- Postdoctoral Fellow, University of Minnesota, 1996 - 1999
- NIH Postdoctoral Fellow, 1997-1999
- Cottrell Scholars Award, 2002
- NSF Career Award, 2004
EricHegg@msu.edu
510 Biochemistry Building
Michigan State University
East Lansing, MI 48824-1319
Phone: 517-353-7120
Fax: 517-353-9334
Lab Members
Current Projects
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Eric L. Hegg Recent Publications
Morrison, M.S.; Cobine, P.A.; Hegg, E.L. "Probing the role of copper in the biosynthesis of the molybdenum cofactor in Escherichia coli and Rhodobacter sphaeroides." J. Biol. Inorg. Chem. 2007 12(8):1129-39. See PubMed
Kreuzer-Martin, H.W.; Lott, M.J.; Ehleringer, J.R.; Hegg, E.L. "Metabolic Processes Account for the Majority of the Intracellular Water in Log-Phase Escherichia coli Cells As Revealed by Hydrogen Isotopes." Biochemistry 2006, 45, 13622-13630. See PubMed
Zhuang, J.; Reddi, A.R.; Wang, Z.; Khodaverdian, B.; Hegg, E.L.; Gibney, B.R. "Evaluating the Roles of the Heme a Sidechains in Cytochrome c Oxidase Using Designed Heme Proteins." Biochemistry 2006,45, 12530-12538. See PubMed
Kreuzer-Martin, H.W.; Ehleringer, J.R.; Hegg, E.L. "Oxygen Isotopes Indicate Most Intracellular Water in Log-Phase Escherichia coli Is Derived from Metabolism." Proc. Natl. Acad. Sci. U.S.A. 2005, 102, 17337-17341. See PubMed
Morrison, S.M.; Cricco, J.A.; Hegg, E.L. "The Biosynthesis of Heme O and Heme A Is Not Regulated by Copper." Biochemistry 2005, 44, 12554-12563. See PubMed
Brown, B.M.; Wang, Z.; Brown, K.R.; Cricco, J.A.; Hegg, E.L. "Heme O Synthase and Heme A Synthase from Bacillus subtilis and Rhodobacter sphaeroides Interact in Escherichia coli." Biochemistry 2004, 43, 13541-13548. See PubMed
Hegg, E.L. "Unraveling the Structure and Mechanism of Acetyl-CoA Synthase." Acc. Chem. Res. 2004, 37, 775-783. See PubMed
Brown, K.R.; Brown, B.M.; Hoagland, E.; Mayne, C.L.; Hegg, E.L. "Heme A Synthase Does Not Incorporate Molecular Oxygen into the Formyl Group of Heme A." Biochemistry 2004, 43, 8616-8624. See PubMed
Hatlevik, Ø.; Blanksma, M.C.; Mathrubootham, V.; Arif, A.M.; Hegg, E.L. "Modeling Carbon Monoxide Dehydrogenase/Acetyl-CoA Synthase (CODH/ACS): A Trinuclear Nickel Complex Employing Deprotonated Amides and Bridging Thiolates." J. Biol. Inorg. Chem. 2004, 9, 238-246. See PubMed
Brown, K.R.; Allan, B.M.; Do, P.; Hegg, E.L. "Identification of Novel Hemes Generated by Heme A Synthase: Evidence for Two Successive Monooxygenase Reactions." Biochemistry 2002, 41, 10906-10913. See PubMed
Mehn, M.P.; Fujisawa, K.; Hegg, E.L.; Que, L., Jr. "Oxygen Activation by Nonheme Iron(II) Complexes: α-Keto Carboxylate versus Carboxylate." J. Am. Chem. Soc. 2003, 125, 7828-7842. See PubMed
Ho, R.Y.N.; Mehn, M.P.; Hegg, E.L.; Liu, A.; Ryle, M.J.; Hausinger, R.P.; Que, L., Jr. "Resonance Raman Studies of the Iron(II)-α-Keto Acid Chromophore in Model and Enzyme Complexes." J. Am. Chem. Soc. 2001, 123, 5022-5029. See PubMed
Hegg, E.L.; Whiting, A.K.; Saari, R.E.; McCracken, J.; Hausinger, R.P; Que, L., Jr. "The Herbicide-Degrading α-Keto Acid-Dependent Enzyme TfdA: Metal Coordination Environment and Mechanistic Insights." Biochemistry 1999, 38, 16714-16726. See PubMed
Hegg, E.L.; Ho, R.Y.N.; Que, L., Jr. "Oxygen Activation and Arene Hydroxylation by Functional Mimics of α-Keto Acid-Dependent Iron(II) Dioxygenases." J. Am. Chem. Soc. 1999, 121, 1972-1973.
Hegg, E.L.; Mortimore, S.H.; Cheung, C.L.; Huyett, J.E.; Powell, D.R., Burstyn, J.N. "Structure - Reactivity Studies in Copper(II) Catalyzed Phosphodiester Hydrolysis." Inorg. Chem. 1999, 38, 2961-2968. See PubMed
Hegg, E.L.; Burstyn, J.N. "Toward the Development of Metal-Based Synthetic Nucleases and Peptidases: A Rationale and Progress Report in Applying the Principles of Coordination Chemistry." Coord. Chem. Rev. 1998, 173, 133-165.
Hegg, E.L.; Que, L., Jr. "The 2-His-1-Carboxylate Facial Triad: An Emerging Structural Motif in Mononuclear Non-Heme Iron(II) Enzymes." Eur. J. Biochem. 1997, 250, 625-629. See PubMed
Hegg, E.L.; Deal, K.A.; Kiessling, L.L.; Burstyn, J.N. "Hydrolysis of Double-Stranded and Single-Stranded RNA in Hairpin Structures by the Copper(II) Macrocycle Cu([9]aneN3)Cl2." Inorg. Chem. 1997, 36, 1715-1718. See PubMed
Hegg, E.L.; Burstyn, J.N. "Copper(II) Macrocycles Cleave Single-Stranded and Double-Stranded DNA under both Aerobic and Anaerobic Conditions." Inorg. Chem. 1996, 35, 7474-7481.
Hegg, E.L.; Burstyn, J.N. "Hydrolysis of Unactivated Peptide Bonds by a Macrocyclic Copper(II) Complex: Cu([9]aneN3)Cl2 Hydrolyzes both Dipeptides and Proteins." J. Am. Chem. Soc. 1995, 117, 7015-7016.
Michot, L.J.; Barres, O.; Hegg, E.L.; Pinnavaia, T.J. "Cointercalation of Al13 Polycations and Nonionic Surfactants in Montmorillonite Clay." Langmuir 1993, 9, 1794-1800.