R. William Henry
Associate Professor
- Ph.D. 1992, University of Alberta, Canada
- Postdoctoral Fellow, 1992-1998, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
henry@msu.edu
409 Biochemistry Building
Michigan State University
East Lansing, MI 48824-1319
Office: 517-353-3980
Lab: 517-353-3980
FAX: 517-353-9334
Lab Home Page
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R. William Henry Recent Publications
Gene regulation by the p53 and RB tumor suppressor proteins
Ullah, Z., M.S. Buckley, D.N. Arnosti, and R.W. Henry. (2007). Retinoblastoma protein regulation by the COP9 signalosome. Mol Biol Cell 18: 1179-86. Abstract
Gridasova, A.A., and Henry, R.W. (2005). The p53 tumor suppressor protein represses human snRNA gene transcription by RNA polymerases II and III independently of sequence specific DNA binding. Mol Cell Biol. 2005 Apr;25(8):3247-60 Acrobat pdf.
Keller, S.A., Ullah, Z., Buckley, M., Henry, R.W., and Arnosti, D.N. (2005). Distinct developmental expression of Retinoblastoma factors in Drosophila. Gene Expression Patterns, 5:411-421. Acrobat pdf.
Hirsch, H.A., Jawdekar, G.W., Lee, K.A., Gu, L., and Henry, R.W. (2004). Distinct mechanisms for repression of RNA polymerase III transcription by the Retinoblastoma tumor suppressor protein. Molecular & Cellular Biology, 24:2989-5999. Acrobat pdf.
Hirsch, H.A., Gu, L., and R. W. Henry (2000). The Retinoblastoma tumor suppressor protein targets distinct core-promoter complexes to regulate RNA polymerase III gene expression. Molecular & Cellular Biology, 20:9182-9191. Acrobat pdf.
The general transcription machinery and human snRNA gene transcription
Jawdekar, G.W. and R.W. Henry. (2008). Transcriptional regulation of human small nuclear RNA genes. Biochim Biophys Acta. 1779:295-305 Abstract
Jawdekar GW, Hanzlowsky A, Hovde SL, Jelencic B, Feig M, Geiger JH, Henry RW. (2006) The unorthodox SNAP50 zinc finger domain contributes to cooperative promoter recognition by human SNAPc. J Biol Chem. 281(41):31050-60. Acrobat pdf.
Hanzlowsky A, Jelencic B, Jawdekar GW, Hinkley CS, Geiger JH, Henry RW. (2006) Co-expression of multiple subunits enables recombinant SNAPC assembly and function for transcription by human RNA polymerases II and III. Protein Expr Purif. 48(2):215-23. Acrobat pdf.
Gu L, Esselman WJ, Henry RW. (2005). Cooperation between small nuclear RNA-activating protein complex (SNAPc) and TATA-box-binding protein antagonizes Protein Kinase CK2 Inhibition of DNA Binding by SNAPc. Journal of Biological Chemistry. 280:27697-704. Acrobat pdf.
Hinkley, C. S., Hirsch, H. A., Gu, L., LaMere, B., and Henry, R.W. (2003). The SNAP190 Myb DNA-binding domain regulates TBP-TATA recognition. Journal of Biological Chemistry, 278:18649-18657. Acrobat pdf.
Hovde, S., Hinkley, C. S., Strong, K., Brooks, A., Gu, L., Henry, R. W., and J. Geiger (2002). Activator recruitment by the general transcription machinery: X-ray structural analysis of the Oct-1 POU domain/human U1 octamer/SNAP190 peptide ternary complex. Genes & Development, 16:2772-2777. Acrobat pdf.
Chen, D., Hinkley, C. S., Henry, R. W., and S. Huang (2002). TBP dynamics in living human cells: constitutive association of TBP with mitotic chromosomes. Molecular Biology of the Cell, 13:276-284. Acrobat pdf.
Henry, R.W., Mittal, V., Ma, B., Kobayashi, R., and N. Hernandez (1998). Assembly of a functional, core promoter complex (SNAPc) shared by RNA polymerase II and III. Genes & Development, 12:2664-2672. Acrobat pdf.
Additional publications
Henry, R.W., Ford, E., Mital, R., Mittal, V., and N. Hernandez (1998). Crossing the line between polymerases: transcription of human snRNA genes by RNA polymerases II and III. Cold Spring Harbor Symp. Quant. Biol. LXIII. pp 111-120. Cold Spring Harbor Laboratory Press, NY.Wong, M.W., Henry, R.W., Ma, B., Kobayashi, R., Klages, N., Matthias, P., Strubin, M., and N. Hernandez (1998). The large subunit of basal transcription factor SNAPc is a Myb domain protein that interacts with Oct-1. . Molecular & Cellular Biology. 18: 368-377.
Grueneberg, D.A., Henry, R.W., Brauer, A., Novina, C.D., Cheriyath, V., Roy, A.L., and M. Gilman (1997). A multifunctional DNA-binding protein that promotes the formation of serum response factor/homeodomain complexes: Identity to TFII-I. Genes & Development. 11: 2482-2493.
Henry, R.W., Sadowski, C.L. , Kobayashi, R. , and N. Hernandez (1996). The SNAP45 subunit of the small nuclear RNA (snRNA) activating protein complex is required for RNA polymerase II and III snRNA gene transcription and interacts with the TATA box binding protein. Proceedings of the National Academy of Science. USA 93: 4289-4293.
Henry, R.W., Ma, B., Sadowski, C.L., Kobayashi, R., and N. Hernandez (1996). Cloning and characterization of SNAP50, a subunit of the snRNA-activating protein complex SNAPc. EMBO J. 15: 7129-7136.
Henry, R.W. and R. Kobayashi (1995). SNAPc: A novel TBP-TAF complex required for transcription by RNA polymerases II and III. Experimental Medicine.13: 69-72.
Henry, R.W., Sadowski, C.L. , Kobayashi, R. , and N. Hernandez (1995). A TBP-TAF complex required for transcription of human snRNA genes by RNA polymerases II and III. Nature 374: 653-657.