Charles G. Hoogstraten
Assistant Professor
- B.S. 1990, Michigan State University, Chemistry & Biochemistry
- Howard Hughes Medical Institute Predoctoral Fellowship, 1990-1995
- Ph.D. 1995, University of Wisconsin - Madison
- Helen Hay Whitney Postdoctoral Fellow, 1995-1998, University of Colorado, Boulder
- Visiting Postdoctoral Fellow/Junior Research Specialist, 1998-2002, UC Davis, Chemistry
hoogstr3@msu.edu
302D Biochemistry Building
Michigan State University
East Lansing, MI 48824-1319
Office: 517-353-3978
FAX: 517-353-9334
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Charles G. Hoogstraten Recent Publications
Hoogstraten, C.G. & Johnson, J.E., Jr. (2008) Metabolic Labeling: Taking advantage of bacterial pathways to prepare spectroscopically useful isotope patterns in proteins and nucleic acids. Concepts Magn. Reson. Ser. A 32, 34-55.
Hoogstraten CG, Sumita M. (2007) Structure-function relationships in RNA and RNP enzymes: Recent advances. Biopolymers. 87:317-328.
Vogt M, Lahiri S, Hoogstraten CG, Britt RD, DeRose VJ. (2006) Coordination environment of a site-bound metal ion in the hammerhead ribozyme determined by 15N and 2H ESEEM spectroscopy. J Am Chem Soc. 27;128(51):16764-70.
Johnson JE Jr, Julien KR, Hoogstraten CG. (2006) Alternate-site isotopic labeling of ribonucleotides for NMR studies of ribose conformational dynamics in RNA. J Biomol NMR. 35(4):261-74.
Hoogstraten, C.G., Grant, C.V., & Britt, R.D. (2002) Water counting: Quantitating the Hydration Level of Metal Ions Bound to Nucleotides and Nucleic Acids. RNA 8, 252-260.
Hoogstraten, C.G., Grant, C.V., Horton, T.E., DeRose, V.J., & Britt, R.D. (2002) Structural Analysis of Metal Ion Ligation to Nucleotides and Nucleic Acids Using Pulsed EPR Spectroscopy. J. Am. Chem. Soc. 124, 834-842.
Summers, J.S., Hoogstraten, C.G., Britt, R.D., Base, K., Shaw, B.R., Ribeiro, A.A., & Crumbliss, A.L. (2001) 31P NMR Probes of Chemical Dynamics: Paramagnetic Relaxation Enhancement of the 1H and 31P NMR Resonances of Methylphosphite and Methylethylphosphate Anions by Selected Metal Complexes. Inorg. Chem. 40, 6547-6554.
Hoogstraten, C.G., Wank, J.R., & Pardi, A. (2000) Active Site Dynamics in the Lead-Dependent Ribozyme. Biochemistry 39, 9951-9958.
Morrissey, S.R., Horton, T.E., Grant, C.V., Hoogstraten, C.G., Britt, R.D., & DeRose, V.J. (1999) Mn2+-Nitrogen interactions in RNA probed by electron spin echo envelope modulation spectroscopy: Application to the hammerhead ribozyme. J. Am. Chem. Soc. 121, 9215-9218.
Hoogstraten, C.G., Legault, P., & Pardi, A. (1998) NMR solution structure of the lead-dependent ribozyme: Evidence for dynamics in RNA catalysis. J. Mol. Biol. 284, 337-350
Legault, P., Hoogstraten, C.G., Metlitzky, E., and Pardi, A. (1998) Order, dynamics, and metal binding in the lead-dependent ribozyme. J. Mol. Biol. 284, 325-335.
Hoogstraten, C.G. & Pardi, A. (1998) Measurement of carbon-phosphorus J coupling constants in RNA using spin-echo difference constant-time HCCH-COSY. J. Magn. Reson 133, 236-240.
Hoogstraten, C.G. & Pardi, A. (1998) Improved distance analysis in RNA using network-editing techniques for overcoming errors due to spin diffusion. J. Biomolec. NMR 11, 85-95.
Hoogstraten, C.G. & Markley, J.L. (1996) Approaches to the determination of more accurate cross-relaxation rates and the effects of improved distance constraints on protein solution structures. in Jardetzky, O. & Lefèvre, J.-F., eds., Dynamics and the Problem of Recognition in Biological Macromolecules. Plenum: New York.