Jon M. Kaguni Recent Publications
MM Felczak, JM Kaguni. (2009) DnaAcos hyperinitiates by circumventing regulatory pathways that control the frequency of initiation in Escherichia coli. Molecular Microbiology. 72:1348-1363.
Chodavarapu S, Gomez R, Vicente M, Kaguni JM. (2008) Escherichia coli Dps interacts with DnaA protein to impede initiation: a model of adaptive mutation. Mol Microbiol. 67(6):1331-46.
Chodavarapu S, Felczak MM, Yaniv JR, Kaguni JM. (2008) Escherichia coli DnaA interacts with HU in initiation at the E. coli replication origin. Mol Microbiol. 67(4):781-92.
Hupert-Kocurek K, Sage JM, Makowska-Grzyska M, Kaguni JM. (2007) A Genetic Method to Analyze Essential Genes of Escherichia coli. Appl Environ Microbiol. 73(21):7075-82.
Kaguni JM. (2006) DnaA: Controlling the initiation of bacterial DNA replication and more. Annu Rev Microbiol. 60:351-375.
Kaguni JM. (2006) DnaA: Controlling the initiation of bacterial DNA replication and more. Annu Rev Microbiol. 60:351-375.
Walker JR, Severson KA, Hermandson MJ, Blinkova A, Carr KM, Kaguni JM. (2006) Escherichia coli DnaA protein: specific biochemical defects of mutant DnaAs reduce initiation frequency to suppress a temperature-sensitive dnaX mutation. Biochimie. 88(1):1-10. Epub 2005 Sep 21.
Felczak MM, Simmons LA, Kaguni JM. (2005) An essential tryptophan of Escherichia coli DnaA protein functions in oligomerization at the E. coli replication origin. J Biol Chem. 280(26):24627-33. Epub 2005 May 5.
Felczak MM, Kaguni JM. (2004) The box VII motif of Escherichia coli DnaA protein is required for DnaA oligomerization at the E. coli replication origin. J Biol Chem.279(49):51156-62. Epub Sep 14, 2004.Simmons LA, Breier AM, Cozzarelli NR, Kaguni JM. (2004) Hyperinitiation of DNA replication in Escherichia coli leads to replication fork collapse and inviability. Mol Microbiol. 51(2):349-58.
Simmons LA, Felczak M, Kaguni JM. (2003) DnaA Protein of Escherichia coli: oligomerization at the E. coli chromosomal origin is required for initiation and involves specific N-terminal amino acids. Mol Microbiol. 49(3):849-58.
Simmons, Lyle A., and Kaguni, Jon M. (2003) The dnaAcos allele of E. coli: hyperactive initiation is due to substitution of A184V and Y271H, resulting in defective ATP binding and aberrant DNA replication control. Mol. Micro. 47(3):755-65.
Carr, Kevin M. and Kaguni, Jon M. (2002) E. coli DnaA protein loads a single DnaB helicase at a DnaA box hairpin. J. Biol. Chem. 277(42)39815-22. Epub Aug 2, 2002.
Ludlam, Anthony V., McNatt, M. and Kaguni, J.M. (2001) Essential amino acids of Escherichia coli DnaC protein in an N-terminal domain interact with DnaB helicase. J. Biol. Chem. 276, 27345-27353.
Carr, Kevin M. and Kaguni, Jon M. (2001) Stoichiometry of DnaA and DnaB protein in initiation at the E. coli chromosomal origin. J. Biol. Chem. 276, 44919-44925.
Sutton, M.D., Carr, K.M., Vincente, M., Kaguni, J.M. (1998) Escherichia coli DnaA protein. The N-terminal domain and loading of DnaB hilicase at the E. coli chromosomal origin. J. Biol. Chem. 273:34255-34262 .
Margulies, C., Kaguni, J.M. (1998) The FIS protein fails to block the binding of DnaA protein to oriC, the Escherichia coli chromosomal origin. Nucleic Acids Res. 26:5170-5175.
Banecki, B., Kaguni, J.M., Marszalek, J. (1998) Role of adenine nucleotides, molecular chaperones and chaperonins in stabilization of the DnaA initiator protein of Escherichia coli. Biochem. Biophys. Acta 1442:39-48 .
Sutton, M.D., Kaguni, J.M. (1997) The Escherichia coli dnA gene: four functional domains. J. Mol. Biol. 274:546-561 .