BRTP Program (Todd Lydic) Genes & Signaling Focus Area (Structural model of human mitochondrial DNA polymerase - L. Kaguni) Structure & Computational Biology Focus Area (Bruker 900 MHz NMR) Plant Biochemistry Focus Area (cDNA Microarray with an Arabidopsis plant and seed - C. Benning)

Jon M. Kaguni
Professor
  • B.S. 1974, University of Notre Dame
  • Ph.D. 1980, University of California, Los Angeles
  • NIH Predoctoral Fellow, 1974-79, University of California, Los Angeles
  • Damon Runyon-Walter Winchell Research Fellow, 1980-82, Stanford University School of Medicine
  • MSU Teacher-Scholar Award, 1991
kaguni@msu.edu
322 Biochemistry Building
Michigan State University
East Lansing, MI 48824-1319
Office: 517-353-6721
Lab: 517-432-3153
FAX: 517-353-9334

Publication search:

Jon M. Kaguni Recent Publications

Chodavarapu S, Gomez R, Vicente M, Kaguni JM. (2008) Escherichia coli Dps interacts with DnaA protein to impede initiation: a model of adaptive mutation. Mol Microbiol. Feb 15; [Epub ahead of print]

Chodavarapu S, Felczak MM, Yaniv JR, Kaguni JM. (2008) Escherichia coli DnaA interacts with HU in initiation at the E. coli replication origin. Mol Microbiol. 67(4):781-92.

Hupert-Kocurek K, Sage JM, Makowska-Grzyska M, Kaguni JM. (2007) A Genetic Method to Analyze Essential Genes of Escherichia coli. Appl Environ Microbiol. 73(21):7075-82.

Kaguni JM. (2006) DnaA: Controlling the initiation of bacterial DNA replication and more. Annu Rev Microbiol. 60:351-375.

Kaguni JM. (2006) DnaA: Controlling the initiation of bacterial DNA replication and more. Annu Rev Microbiol. 60:351-375.

Walker JR, Severson KA, Hermandson MJ, Blinkova A, Carr KM, Kaguni JM. (2006) Escherichia coli DnaA protein: specific biochemical defects of mutant DnaAs reduce initiation frequency to suppress a temperature-sensitive dnaX mutation. Biochimie. 88(1):1-10. Epub 2005 Sep 21.

Felczak MM, Simmons LA, Kaguni JM. (2005) An essential tryptophan of Escherichia coli DnaA protein functions in oligomerization at the E. coli replication origin. J Biol Chem. 280(26):24627-33. Epub 2005 May 5.

Felczak MM, Kaguni JM. (2004) The box VII motif of Escherichia coli DnaA protein is required for DnaA oligomerization at the E. coli replication origin. J Biol Chem.279(49):51156-62. Epub Sep 14, 2004.

Simmons LA, Breier AM, Cozzarelli NR, Kaguni JM. (2004) Hyperinitiation of DNA replication in Escherichia coli leads to replication fork collapse and inviability. Mol Microbiol. 51(2):349-58.

Simmons LA, Felczak M, Kaguni JM. (2003) DnaA Protein of Escherichia coli: oligomerization at the E. coli chromosomal origin is required for initiation and involves specific N-terminal amino acids. Mol Microbiol. 49(3):849-58.

Simmons, Lyle A., and Kaguni, Jon M. (2003) The dnaAcos allele of E. coli: hyperactive initiation is due to substitution of A184V and Y271H, resulting in defective ATP binding and aberrant DNA replication control. Mol. Micro. 47(3):755-65.

Carr, Kevin M. and Kaguni, Jon M. (2002) E. coli DnaA protein loads a single DnaB helicase at a DnaA box hairpin. J. Biol. Chem. 277(42)39815-22. Epub Aug 2, 2002.

Ludlam, Anthony V., McNatt, M. and Kaguni, J.M. (2001) Essential amino acids of Escherichia coli DnaC protein in an N-terminal domain interact with DnaB helicase. J. Biol. Chem. 276, 27345-27353.

Carr, Kevin M. and Kaguni, Jon M. (2001) Stoichiometry of DnaA and DnaB protein in initiation at the E. coli chromosomal origin. J. Biol. Chem. 276, 44919-44925.

Sutton, M.D., Carr, K.M., Vincente, M., Kaguni, J.M. (1998) Escherichia coli DnaA protein. The N-terminal domain and loading of DnaB hilicase at the E. coli chromosomal origin. J. Biol. Chem. 273:34255-34262 .

Margulies, C., Kaguni, J.M. (1998) The FIS protein fails to block the binding of DnaA protein to oriC, the Escherichia coli chromosomal origin. Nucleic Acids Res. 26:5170-5175.

Banecki, B., Kaguni, J.M., Marszalek, J. (1998) Role of adenine nucleotides, molecular chaperones and chaperonins in stabilization of the DnaA initiator protein of Escherichia coli. Biochem. Biophys. Acta 1442:39-48 .

Sutton, M.D., Kaguni, J.M. (1997) The Escherichia coli dnA gene: four functional domains. J. Mol. Biol. 274:546-561 .

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