Lee R. Kroos
Professor
Associate Chair

• B.S. 1981, Bowling Green State University
• Ph.D. 1986, Stanford University
• NSF Predoctoral Fellow, 1981-84, Stanford University
• Helen Hay Whitney Postdoctoral Fellow, 1986-88, Harvard University

kroos@msu.edu
422 Biochemistry Building
Michigan State University
East Lansing, MI 48824-1319
Office: 517-355-9726
Lab: 517-353-0809
FAX: 517-353-9334

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Lee Kroos Recent Publications

Daisuke I, Zhou R, Feig M, Kroos L. Evidence that the Bacillus subtilis SpoIIGA protein is a novel type of signal-transducing aspartic protease. J. Biol. Chem, March 31, 2008. Epub ahead of print. Link to publication.

Kroos L. The Bacillus and Myxococcus developmental networks and their transcriptional regulators. Annu Rev Genet. 2007;41:13-39.

Wang L, Perpich J, Driks A, Kroos L. 2007. Maintaining the transcription factor SpoIIID level late during sporulation causes spore defects in Bacillus subtilis. J Bacteriol. 189(20):7302-9.

Wang L, Perpich J, Driks A, Kroos L. 2007. One perturbation of the mother cell gene regulatory network suppresses the effects of another during sporulation of Bacillus subtilis. J Bacteriol. 189(23):8467-73.

Viswanathan P, Ueki T, Inouye S, Kroos L. 2007. Combinatorial regulation of genes essential for Myxococcus xanthus development involves a response regulator and a LysR-type regulator. Proc Natl Acad Sci U S A. 8;104(19):7969-74.

Viswanathan P, Murphy K, Julien B, Garza AG, Kroos L. 2007. Regulation of dev, an Operon That Includes Genes Essential for Myxococcus xanthus Development and CRISPR-Associated Genes and Repeats. J Bacteriol. 189(10):3738-50.

Viswanathan, K., P. Viswanathan, and L. Kroos 2006. Mutational analysis of the Myxococcus xanthus W4406 promoter region reveals an upstream negative regulatory element that mediates C-signal dependence. J. Bacteriol. 188:515-524.

Viswanathan, P., M. Singer, and L. Kroos 2006. Role of sD in regulating genes and signals during Myxococcus xanthus development. J. Bacteriol. 188:3246-3256.

Yoder-Himes, D.R. and L. Kroos 2006. Regulation of the Myxococcus xanthus C-signal-dependent W4400 promoter by the essential developmental protein FruA. J. Bacteriol. 188:5167-5176.

Zhou R, Kroos L. 2005. Serine proteases from two cell types target different components of a complex that governs regulated intramembrane proteolysis of pro-sigmaK during Bacillus subtilis development. Mol Microbiol. 58(3):835-46.

Loconto J, Viswanathan P, Nowak SJ, Gloudemans M, Kroos L. 2005. Identification of the omega4406 regulatory region, a developmental promoter of Myxococcus xanthus, and a DNA segment responsible for chromosomal position-dependent inhibition of gene expression. J Bacteriol. 187(12):4149-62.

Kroos L. 2005. Eukaryotic-like signaling and gene regulation in a prokaryote that undergoes multicellular development. Proc Natl Acad Sci U S A. 102(8):2681-2. Epub 2005 Feb 14.

Prince H, Zhou R, Kroos L. 2005. Substrate requirements for regulated intramembrane proteolysis of Bacillus subtilis pro-sigmaK. J Bacteriol. 187(3):961-71.

Srinivasan D, Kroos L. 2004. Mutational analysis of the fruA promoter region demonstrates that C-Box and 5-base-pair elements are important for expression of an essential developmental gene of Myxococcus xanthus. J Bacteriol. 186(17):5961-7.

Yoder DR, Kroos L. 2004. Mutational analysis of the Myxococcus xanthus Omicron4499 promoter region reveals shared and unique properties in comparison with other C-signal-dependent promoters. J Bacteriol. 186(12):3766-76.

Zhou R, Kroos L. 2004. BofA protein inhibits intramembrane proteolysis of pro-sigmaK in an intercompartmental signaling pathway during Bacillus subtilis sporulation. Proc Natl Acad Sci U S A. 101(17):6385-90. Epub 2004 Apr 15.

Yoder DR, Kroos L. 2004. Mutational analysis of the Myxococcus xanthus Omega4400 promoter region provides insight into developmental gene regulation by C signaling. J Bacteriol.186(3):661-71.

Viswanathan, P. and L. Kroos 2003. Cis-elements necessary for developmental expression of a Myxococcus xanthus gene that depends on C signaling. J. Bacteriol. 185:1405-1414.

Kroos, L. and J.R. Maddock 2003. Prokaryotic Development: Emerging Insights. J. Bacteriol. 185:1128-1146.

Hao, T., D. Biran, G.J. Velicer, and L. Kroos 2002. Identification of the 4514 regulatory region, a developmental promoter of Myxococcus xanthus that is transcribed in vitro by the major vegetative RNA polymerase. J. Bacteriol. 184:3348-3359.

Kroos, L., Y.-T. N. Yu, D. Mills, and S. Ferguson-Miller 2002. Forespore signaling is necessary for pro-sK processing during Bacillus subtilis sporulation despite loss of SpoIVFA upon translational arrest. J. Bacteriol. 184:5393-5401

Ichikawa, H. and L. Kroos. 2000. Combined action of two transcription factors regulates genes encoding spore coat proteins of Bacillus subtilis. J. Biol. Chem. 275:13849-13855.

Yu, Y.-T., N. and L. Kroos. 2000. Evidence that SpoIVFB is a novel type of membrane metalloprotease governing intercompartmental communication during Bacillus subtilis sporulation. J. Bacteriol. 182:3305-3309.

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