Aizhuo Liu Research Interests continued
2.) New trends of NMR technique development have been towards the structure determination of even larger systems, including integral membrane proteins, and the extraction of new parameters for the structural and dynamic characterizations. One of my focuses in this area is the direct detection of hydrogen bonds in a macromolecule and between molecules in a complex. Information on hydrogen bond networks is very important for the study of enzyme catalysis and molecular recognition. The introduction of a 900 MHz NMR instrument on MSU campus through the Michigan Life Science Corridor should provide us with a unique facility to conduct method development for this purpose.
3.) Advanced NMR techniques for drug development. NMR is one of most important techniques in drug development and has been used in many stages in the process, from compound screening, structural characterization of both small ligand molecules and large protein targets, to lead generation and modification. One of my efforts is to develop new NMR methods, such as 19F-NMR techniques, for the improvement of the efficiency of compound screening and the enhancement of the information on molecular structure, dynamics, and intermolecular interactions.
Full text Liu Research Interests