Aizhuo Liu
Director, NMR Facility
- B.S. 1984, Jilin University, China
- M.S. 1987, Changchun Institute of Applied Chemistry (CIAC), Chinese Academy of Sciences
- Ph.D. 1999, Swiss Federal Institute of Technology Zurich (ETH Zurich)
- Assistant/Associate Professor, 1987-1995, CIAC, Chinese Academy of Sciences
- Research Fellow/Research Associate, 1999-2000, Memorial Sloan-Kettering Cancer Center (MSKCC), New York
- Protein NMR Group Leader, 2000-2003, Tularik Inc. South San Francisco
liua@msu.edu
311 Biochemistry Building
Michigan State University
East Lansing, MI 48824-1319
Office: 517-353-4620
FAX: 517-353-9334
NMR Facility
Publication search:
Aizhuo Liu Recent Publications
Liu A, Lu Z, Wang J, Yao L, Li Y, Yan H. (2008) NMR detection of bifurcated hydrogen bonds in large proteins. J Am Chem Soc. 130(8):2428-9. Link to pdf
Liu, A., Yao, L., Li, Y., and Yan, H. (2007) TROSY of side-chain amides in large proteins. J. Magn Reson. 186(2)319-326. Link to pdf
Liu, A., Li, Y., Yao, L., and Yan, H. (2006) Simultaneous NMR assignment of backbone and side chain amides in large proteins with IS-TROSY. J. Biomol. NMR 36, 205-214. Link to pdf
Yao, L., Li, Y. Wu, Y. Liu, A., and Yan, H. (2005) Product release is rate-limiting in the activation of the prodrug 5-Fluorocytosine by yeast cytosine deaminase. Biochemistry 44, 5940-5947. Link to pdf
Liu, A., Luginbühl, P., Zerbe, O., Ortenzi, C., Luporini, P., and Wüthrich, K. (2001) NMR structure of the pheromone Er-22 from Euplotes raikovi. J. Biomol. NMR. 19, 75-78. Link to pdf
Liu, A., Majumdar, A., Jiang, F., Chernichenko, N., Skripkin, E., and Patel, D.J. (2000) NMR detection of intermolecular N-H···N hydrogen bonds in the human T cell leukemia virus-1 Rex peptide-RNA aptamer complex. J. Am. Chem. Soc. 122, 11226-11227. Link to pdf
Liu, A., Majumdar, A., Hu, W., Kettani, A., Skripkin, E., Patel, D.J. (2000) NMR detection of N-H···O=C hydrogen bonds in 13C,15N-labeled nucleic acids. J. Am. Chem. Soc. 122, 3206-3210. Link to pdf
Liu, A., Hu, W., Majumdar, A., Rosen, M.K., and Patel, D.J. (2000) NMR detection of side chain-side chain hydrogen bonding interactions in 13C/15N-labeled proteins. J. Biomol. NMR. 17, 305-310. Link to pdf
Liu, A., Hu, W., Majumdar, A., Rosen, M.K., and Patel, D.J. (2000) Detection of very weak side chain-main chain hydrogen bonding interactions in medium-size 13C/15N-labeled proteins by sensitivity-enhanced NMR spectroscopy. J. Biomol. NMR. 17, 79-82. Link to pdf
Liu, A., Hu, W., Qamar, S., and Majumdar, A. (2000) Sensitivity enhanced NMR spectroscopy by quenching scalar coupling mediated relaxation: application to the direct observation of hydrogen bonds in 13C/15N-labeled proteins. J. Biomol. NMR. 17, 55-61. Link to pdf
Liu, A., Riek, R., Wider, G., von Schroetter, C., Zahn, R., and Wüthrich, K. (2000) NMR experiments for resonance assignments of 13C, 15N doubly-labeled flexible polypeptides: application to the human prion protein hPrP(23-230). J. Biomol. NMR. 16, 127-38. Link to pdf
Zahn, R., Liu, A., Lührs, T., Riek, R., von Schroetter, C., López, García F., Billeter, M., Calzolai, L., Wider, G., and Wüthrich, K. (2000) NMR solution structure of the human prion protein. Proc. Natl. Acad. Sci. U S A. 97, 145-50. Link to pdf
Riek, R., Prêcheur, B., Wang, Y., Mackay, E.A., Wider, G., Güntert, P., Liu, A., Kagi, J.H., and Wüthrich, K. (1999) NMR structure of the sea urchin (Strongylocentrotus purpuratus) metallothionein MTA. J. Mol. Biol. 291, 417-28. Link to pdf
Liu, A., Riek, R., Zahn, R., Hornemann, S., Glockshuber, R., Wüthrich, K. (1999) Peptides and proteins in neurodegenerative disease: helix propensity of a polypeptide containing helix 1 of the mouse prion protein studied by NMR and CD spectroscopy. Biopolymers. 51, 145-52.Link to pdf