Gavin E. Reid
Assistant Professor

Ph.D. 2000, University of Melbourne, Australia
Post Doctoral Research Fellow, 2000-2002, Purdue University

reid@chemistry.msu.edu
234 Chemistry Building
Michigan State University
East Lansing, MI 48824-1322
Office: 517-355-9715 x198
Lab: 517-355-9715 x209
Fax: 517 353-1973

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Gavin E. Reid

Research Interests

The mixture complexity, dynamic range and diversity of transcriptional, translation and post translational modifications associated with protein expression, as well as the complex array of specific protein-protein interactions involved in the regulation of cellular function, presents a significant analytical challenge to mass spectrometry (MS) based proteomic methods employed for characterization of the hitherto unknown functional role of the thousands of genes identified from recent genome sequencing initiatives.

Research in our laboratory is broadly directed toward the development and application of novel mass spectrometry based chemistries and instrumentation to address these challenges. Aspects of this research include:
(i) systematic examination of the fundamental gas-phase ion chemistries of amino acids, peptides and proteins in order to determine the mechanisms and other factors influencing their fragmentation reactions;

The presence of post-translationally modified (PTM) amino acid residues within a peptide sequence often has a dramatic effect on the fragmentation behavior of its protonated ions under low energy collision induced dissociation (CID) tandem mass spectrometry (MS/MS) conditions. MORE

Recent Publications

Palumbo, A.M., Tepe, J.J. and Reid, G.E. (2007) Mechanistic Insights into the Multistage Gas-Phase Fragmentation Behavior of Phosphoserine- and Phosphothreonine-containing Peptides. J. Proteome Res. In Press.

Meyer, J., Froelich, J.M., Reid, G.E., Karunarathne, W. and Spence, D. (2007) Metal-activated C-peptide Facilitates Glucose Clearance and the Release of a Nitric Oxide Stimulus via the GLUT1 Transporter. Diabetologia. In Press.

Lioe, H., Laskin, J., Reid, G.E. and O’Hair, R.A.J. (2007) Energetics and Dynamics of the Fragmentation Reactions of Protonated Peptides containing Methionine Sulfoxide or Aspartic Acid via Energy- and Time-Resolved Surface Induced Dissociation. J. Phys. Chem. A. 111: 10580-10588.

Froelich J.M. and Reid, G.E. (2007) Mechanisms for the Proton Mobility Dependant Gas-Phase Fragmentation Reactions of S-alkyl Cysteine Sulfoxide-containing Peptide Ions. J. Am. Soc. Mass Spectrom. 18: 1690-1705.

Lioe, H., O'Hair, R.A.J. Gronert, S., Austin, A. and Reid, G.E. (2007) Experimental and Theoretical proton affinities of Methionine, Methionine sulfoxide and their N- and C-terminal derivatives. Int. J. Mass Spectrom. 267: 220-232.