The focus area entitled, "Genes and Signaling" brings
together the shared interests of half our faculty. 
Under the topic of the enzymology of nucleic acids, specific research programs are on DNA replication and mechanisms to maintain the genetic
integrity of DNA, including the study of biochemical pathways that lead to aberrant cell proliferation or cancer when cells experience DNA damage.
Several research programs study the mechanism of
transcription and its regulation, and an exciting new initiative of interdisciplinary research centers on Gene Expression in Development and Disease.
Other
laboratories investigate RNA-based catalysis, RNA splicing, and signalling pathways in response to various stimuli and include apoptotic pathways leading to programmed cell death.
Composing one of
the three major research areas of the Department, these strong research programs directed by leading investigators constitute an internationally-recognized strength at Michigan State University. The
addition of new faculty provides added dimension to this focus area, and builds on our strength. Students and postdocs who work in this exciting focus area make important scientific contributions
while receiving outstanding training in preparation for successful scientific careers.