MSU BMB Research Focus Areas

Research in the Department covers a broad spectrum of topics in modern biochemistry, ranging from structural biology to gene activity and regulation. Human disease processes such as cancer and immune function are the focus of research involving DNA replication, gene regulation, and tumor suppressor activity.

Enzyme function and drug development are important connections to the fields of pharmaceuticals and biotechnology.

Plant research projects concentrating on the biochemistry of lipid and carbohydrate biosynthesis have the potential for achieving major gains in the agricultural sector.

Structural modeling, computation, and design are integrated into many of these areas of research.

We have grouped the research areas into three general domains. You will find that many of our groups have connections to all three of these areas.

Flag-tagged mixed-lineage kinase 3 (green) localized in HeLa cells by confocal fluorescence microscopy.  Mitochondria are visualized with MitoTracker Red.  Photo by Geou-Yarh (Stancy) Liou in Kathy Gallo's lab.

    Genes and Signaling


  • Signaling Pathways   & Apoptosis
  • DNA Replication;   Mutagenesis & Human   Disease
  • Gene Expression & Regulation
  • Toxicology
Confocal image of a pollinated pistil from a transgenic Arabidopsis plant that expresses green fluorescence protein (GFP) under the control of the acyl-CoA oxidase promoter.  Photo by Abe Koo in Gregg Howe's lab.




A peptidyl inhibitor in complex with the drug design target, HIV protease.
The blue spheres represent bound water molecules.  Graphics image by Volker
Schnecke, postdoctoral fellow in Leslie Kuhn's lab.

    Structural and Computational Biology
  • Computational Modeling
  • X-ray Crystallography & NMR
  • Membranes & Mebrane   Proteins
  • Structure-Function Studies
  • Enzyme Catalysis &   Metalloproteins