Protein Structural Analysis and Design Lab

<BODY BACKGROUND="graphics/chalk.jpg"> <CENTER> <STRONG> Through computational analysis of molecular structures, we seek to understand how proteins fold, recognize, and bind to other molecules. This knowledge is used for modeling protein structures and designing inhibitors, in collaboration with computer scientists, chemists, molecular biologists, and physicians. Our focus is on decoding the factors contributing to the specificity of protein-ligand interactions, including chemistry, flexibility, and solvation. This enables our development of new approaches for modeling protein and ligand flexibility and performing high-throughput screening for inhibitor discovery. <P> <I>Leslie A. Kuhn, Lab Director</I> </STRONG> <P> <HR> <H1 ALIGN="center">Protein Structural Analysis and Design Laboratory</H1> </CENTER> <UL> <LI> <A HREF="people.html">Group Members</A> <P> <LI> <A HREF="publications.html">Publications</A> <P> <LI> <A HREF="links.html">Internet Places</A> <P> <LI> <A HREF="http://www.bch.msu.edu">Department of Biochemistry and Molecular Biology</A> <LI> <A HREF="http://biomodel.msu.edu">MSU Quantitative Biology and Modeling Initiative</A> <P> <LI> <A HREF="http://www.msu.edu">Michigan State University</A> </UL> </BODY>