Undergraduate Publications

The Biochemistry & Molecular Biology Department at Michigan State University is research-intensive. Our mission in undergraduate education is to combine research with excellence in undergraduate instruction. By maintaining a world-class research effort, we teach the latest developments in biochemistry and molecular biology to our undergraduate students, making undergraduate education more relevant and sophisticated. Furthermore, we provide opportunity and resources for undergraduates to participate in noteworthy research.

The following students have published research findings from their work with BMB faculty.

Student
Publication
Mentor
James Sierakowski
Substituent Effects on the Gas-Phase Fragmentation Reactions of Sulfonium Ion Containing Peptides. 2007. Rapid Commun. Mass Spectrom. 21: 1230-1238.
Authors: Sierakowski, J., Amunugama, M., Roberts, K.D and Reid, G.E.

Matt Moll
A Heteromeric Plastidic Pyruvate Kinase Complex Involved in Seed Oil Biosynthesis in Arabidopsis. 2007. Plant Cell. Jun;19(6):2006-22
Authors: Andre C, Froehlich JE, Moll MR, Benning C.
Melody Campbell
Metal ligand substitution and evidence for quinone formation in taurine/a-ketoglutarate dioxygenase. 2007. J. Inorg. Biochem. 101:797-808.
Authors: Grzyska, P. K., T. A. Müller, M. G. Campbell, and R. P. Hausinger.

Brandon Guelette
Elizabeth Bartlett
Identification of a unique splice site variant in SLC39A4 in bovine hereditary zinc deficiency, lethal trait A46: An anmial model of acrodermatitis enteropathica. 2006. Genomics. 88(4):521-526.
Authors: Vilma Yuzbasiyan-Gurkan and Elizabeth Bartlett 		Vilma Yuzbasiyan-Gurkan, Depts of Microbiology & Molecular Genetics and Small Animal Clinical Sciences
Effect of crystal freezing and small molecule binding on internal cavity size in a large protein: X-ray and docking studies of lipoxygenase at ambient and low temperature at 2.0 Ã resolution. J.  Acta Cryst D62:766-775, 2006.
Authors: Skrzypczak-Jankun E, Borbulevych OY, Zavodszky MI, Baranski MR, Padmanabhan K, Petricek V, Jankun

Maria I. Zavodszky

Zimin Zhao
Maspin retards cell detachment via a novel interaction with the urokinase-type plasminogen activator/urokinase-type plasminogen activator receptor system. 2006. Cancer Research. 66(8) 4173-4181.
Authors: S. Yin, J. Lockett, Y. Meng, H Biliran, Jr., G.E. Blouse, N. Reddy, Z. Zhao, X. Lin, J. Anagli, M. Cher, S. Sheng		 Sijie Sheng, Dept of Pathology, Wayne State University School of Medicine

Adam Cornish
Phosphatidylglycerol biosynthesis in chloroplasts of Arabidopsis mutants deficient in acyl-ACP glycerol-3- phosphate acyltransferase. 2006. The Plant Journal. 47:296-309.
Authors: Changcheng Xu, Bin Yu, Adam J. Cornish, John E. Froehlich, and Christoph Benning

Anjali Rohatgi
 Discovering new classes of Brugia malayi asparaginyl-tRNA synthetase inhibitors and relating specificity to conformational change. 2006. J. Comput Aided Mol Des. 20(3):159-78.
Authors: Sai Chetan K. Sukuru, Thibaut Crepin, Youli Milev, Liesl C. Marsh, Jonathan B. Hill, Regan J. Anderson, Jonathan C. Morris, Anjali Rohatgi, Gavin O’Mahony, Morten Grøtli, Franck Danel, Malcolm G. P. Page, Michael Hartlein, Stephen Cusack, Michael A. Kron, Leslie A. Kuhn
Nancy Y. Lin
Transport of galectin-3 between the nucleus and cytoplasm. II. Identification of the signal for nuclear export. 2006. Glycobiology vol. 16 no. 7 pp. 612–622.
Authors: Su-Yin Li, Peter J. Davidson, Nancy Y. Lin, Ronald J. Patterson, John L. Wang, and Eric J. Arnoys
Kartik Viswanathan
 Mutational Analysis of the Myxococcus xanthus Ω4406 Promoter Region Reveals an Upstream Negative Regulatory Element That Mediates C-Signal Dependence. 2006. J. of Bacteriology. 515-524.
Authors: Kartik Viswanathan, Poorna Viswanathan, Lee Kroos
Jennifer Loconto


Scott J. Nowak
 Identification of the Ω4406 Regulatory Region, a Developmental Promoter of Myxococcus xanthus, and a DNA Segment Responsible for Chromosomal Position-Dependent Inhibition of Gene Expression. 2005. J. of Bacteriology, 4149-4162.
Authors: Jennifer Loconto, Poorna Viswanathan, Scott J. Nowak, Monica Gloudemans, Lee Kroos

Katie Zobeck
Human RNA Polymerase II Elongation in Slow Motion: Role of the TFIIF RAP74 .1 Helix in Nucleoside Triphosphate-Driven Translocation. 2005. Molec Cell Biol. Vol. 25, No. 9.
Authors: Chunfen Zhang, Katie L. Zobeck, and Zachary F. Burton
Sarah Ward
Purification and properties of the Klebsiella aerogenes UreE metal-binding domain, a functional metallochaperone of urease.2005. J. Bacteriol. 187:3581-3585.
Authors: Mulrooney, S. B., S. K. Ward, and R. P. Hausinger.

Greta R. Monterosso
 Steady-State and Transient Kinetic Analyses of Taurine/R-Ketoglutarate Dioxygenase: Effects of Oxygen Concentration, Alternative Sulfonates, and Active-Site Variants on the FeIV-oxo Intermediate. 2005. Biochemistry. 44, 3845-3855.
Authors: Piotr K. Grzyska, Matthew J. Ryle, Greta R. Monterosso, Jian Liu, David P. Ballou,| and Robert P. Hausinger

Anthony T. Lagina III
 Physiological and biochemical defects in functional interactions of mitochondrial DNA polymerase and DNA-binding mutants of single-stranded DNA-binding protein. 2004. J.Biol. Chem. 279: 17047-17053.
Authors: Lefai E, Calleja M, Ruiz de Mena I, Lagina III AT, Kaguni LS, Garesse R.

Sze-ling Ng
 A tethered catalysis two-hybrid system to identify protein-protein interactions requiring post-translational modifications. 2004. Nature Biotechnology (22)888-892.
Authors: Guo, D, Hazbun, T, Xu, X, Ng, S-L, Fields, S, and Kuo, M-H.

Greta R. Monterosso
 Direct Detection of Oxygen Intermediates in the Non-Heme Fe Enzyme Taurine/alpha-Ketoglutarate Dioxygenase. 2004. J. Am. Chem. Soc. Biochemistry. 44, 3845-3855.
Authors: Proshlyakov, D, Henshaw, T, Monterosso, G, Ryle, M, and Hausinger, R.
Mary E. Piper
Characterization of the branching patterns of glycogen branching enzyme truncated on the N-terminus. 2004. Archives of Biochemistry and Biophysics 418 (2003) 34-38
Authors: Devillers, C., Piper, M., Ballicora, M., Preiss, J.

Woo Moon
Efficient production of recombinant human transcription factor IIE. 2004. Protein Expression and Purification. 34:317–323.
Authors: Woo J. Moon, Jessica A. Apostol, Aaron J. McBride, Lata I. Shukla, Arik Dvir, Zachary F. Burton
Jennifer Dubay
 An assay for adenosine 5'-diphosphate (ADP)-glucose pyrophosphorylase that measures the synthesis of radioactive ADP-glucose with glycogen synthase. Analytical Biochemistry. 324 (2004) 52-59.
Authors: Yep, A., Bejar, C., Ballicora, M., Dubay, J., Iglesias, A., Preiss, J.
Michael E. Ruckle
Todd A. Lydic
 The sulfolipids 2'-O-acyl-sulfoquinovosyldiacylglycerol and sulfoquinovosyldiacylglycerol are absent from a Chlamydomonas reinhardtii mutant deleted in SQD1. Plant Physiol. 2003 Oct;133(2):864-74. Epub 2003 Sep 18.
Authors: Riekhof WR, Ruckle ME, Lydic TA, Sears BB, Benning C.
Daniel C. Ducat
 Overcoming obtacles in DNA sequencing of expression plasmids for short interfering RNAs. (2003) Biotechniques 34:(6)1143-1144.
Authors: Ducat DC, Herrera FJ, Triezenberg, SJ.
Tommy Auchtung
Intrinsic tryptophan fluorescence as a probe of metal and a-ketoglutarate binding to TfdA, a mononuclear non-heme iron oxygenase. 2003 .J. Inorg. Biochem. 93:66-70.
Authors: Dunning Hotopp, J. C., T. A. Auchtung, D. A. Hogan, and R. P. Hausinger.
Christopher Eakin
 The pgp1 mutant locus of Arabidopsis encodes a phosphatidylglycerolphosphate synthase with impaired activity. Plant Physiol. 2002 Jun;129(2):594-604.
Authors: Xu C, Hartel H, Wada H, Hagio M, Yu B, Eakin C, Benning C.

Janel D. Funk
 A key role for the α-1 helix of human RAP74 in the initiation and elongation of RNA chains. 2002. J. Biol. Chem. 277, 46998-47003.
Authors: Funk JD, Nedialkov YA, Xu D, Burton ZF
Jamie Hubert
Digalactosyldiacylglcyerol synthesis in chloroplasts of the Arabidopsis dgd1 mutant. 2002. Plant Physiol. 128:885-895.
Authors: Klaus, D., Härtel, H., Fitzpatrick, L., Froehlich, J., Hubert, J., Benning, C., and P. Dörmann.
Brooke A. Woolley
 Anticoagulants prevent monocrotaline-induced hepatic parenchymal cell injury but not endothelial cell injury in the rat. Toxicol Appl Pharmacol 2002 May 1;180(3):186-96.
Authors: Copple BL, Woolley B, Banes A, Ganey PE, Roth RA.
Anthony V. Ludlam
 Essential amino acids of Escherichia coli DnaC protein in an N-terminal domain interact with DnaB helicase. J. Biol. Chem. 2001. 276:27345-27353.
Authors: Ludlam AV, McNatt MW, Carr K, Kaguni JM.
Stacy (Trzos) Bloom
Two unrelated phosphoenolpyruvate carboxylase polypeptides physically interact in the high molecular mass isoforms of this enzyme in the unicellular green alga Selenastrum minutum. J Biol Chem. 2001 Apr 20;276(16):12588-97.
Authors: Rivoal J, Trzos S, Gage DA, Plaxton WC, Turpin DH.

Bethany Strunk

Jelani Thomas

Kevin L. Wright
Brandon A. Pabst
 Role of CtBP in transcriptional repression by the Drosophila giant protein. Dev Biol. 2001. Nov 15;239(2):229-40.
Authors: Strunk B, Struffi P, Wright K, Pabst B, Thomas J, Qin L, Arnosti DN.

Anthony T. Lagina III
 Overexpression of the catalytic subunit of DNA polymerase γ results in depletion of mitochondrial DNA in Drosophila melanogaster. Mol Gen Genet. 2000. Sep: 264( 1-2):37-46.
Authors: Lefai E, Calleja M, Ruiz de Mena I, Lagina III AT, Kaguni LS, Garesse R.
Kyle P. Openo
 Galectin-3 expression and subcellular localization in senescent human fibroblasts. Exp Cell Res. 2000 Mar 15;255(2):278-90.
Authors: Openo KP, Kadrofske MM, Patterson RJ, Wang JL.

Catherine E. Yurk

Roxane L. Amey
Amelia R. Anderson
Sarah Moore
dCtBP dependent and independent repression activities of the Drosophila "Knirps protein" (2000) Mol. Cell. Biol. 20: 7247-7258.
Authors: Keller SA, Mao Y, Struffi P, Margulies C, Yurk, CE, Anderson AR, Amey RL, Moore S, Ebels JM, Foley K, Corado M, Arnosti DN

Gavin F. Hewitt

Tory Priputin

Bethany Strunk

Roxane L. Amey
Brandon A. Pabst
Transcriptional repression by the Drosophila Giant protein: cis element positioning provides an alternative means of interpreting an effector gradient. 1999. Development 126 (6) 1201-1210.
Authors: Hewitt GF, Strunk BS, Priputin T, Wang X-D, Amey R, Pabst, BA, Kosman D, Reinitz J, Arnosti, D.N.
Michael E. Young
 GTP promotes the formation of early-import intermediates but is not required during the translocation step of protein import into chloroplasts. (1999) Plant Physiol. 121:237-243 Authors: Young ME, Keegstra K, Froehlich JE
Tommy Auchtung
Cloning and characterization of a sulfonate/a-ketoglutarate dioxygenase from Saccharomyces cerevisiae. 1999. J. Bacteriol. 181:5876-5879.
Authors: Hogan,D. A., T. A. Auchtung, and R. P. Hausinger.